SC-39026, a specific human neutrophil elastase inhibitor.
作者信息
Nakao A, Partis R A, Jung G P, Mueller R A
出版信息
Biochem Biophys Res Commun. 1987 Sep 15;147(2):666-74. doi: 10.1016/0006-291x(87)90982-x.
PMID:3115265
Abstract
SC-39026, (+/-) 2-chloro-4-(1-hydroxyoctadecyl)benzoic acid, inhibits human neutrophil elastase with an IC50 of 0.5 microM (KI of 1.5 microM). Its inhibition of elastase is reversible and noncompetitive at low concentrations (0.5-1.25 microM). Inhibition is "mixed" at higher inhibitor concentrations. SC-39026 is inactive against hog pancreatic elastase, bovine alpha-chymotrypsin and Pseudomonas aeruginosa elastase, but does inhibit human neutrophil cathepsin G with an IC50 of approximately 2.5 microM. Neutrophil elastases isolated from rat, hamster, rabbit and hog are also inhibited by SC-39026.
摘要
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