Rao K R, Patel A R
Department of Medicine, Cook County Hospital, Chicago, Illinois.
Blood Cells. 1987;12(3):543-53.
The light-microscope finding of red cell membrane fragments in the form of long filamentous processes and myelin bodies in the blood smears of a patient with sickle cell anemia has recently been described. This phenomenon has been termed erythrocytic ecdysis. We examined the blood smears of all sickle cell anemia patients admitted to the Cook County Hospital and those attending the hemoglobinopathy clinic between October 1979 and December 1981. Nine instances of erythrocytic ecdysis were uncovered. Associated clinical conditions included congestive heart failure, acute viral syndrome, pneumonia, and metastatic malignancy. Transient ecdysis associated with congestive heart failure was noted for one patient during two separate admissions one year apart. Ecdysis is a transient form of erythrocytic fragmentation occurring in sickle cell anemia. Its pathogenesis is unknown. The role of regional circulatory stasis and hypoxia in the induction of erythrocyte membrane damage in sickle cell anemia needs investigation.
最近报道了在一名镰状细胞贫血患者的血涂片中发现红细胞膜碎片呈长丝状突起和髓鞘体的光学显微镜检查结果。这种现象被称为红细胞脱逸。我们检查了1979年10月至1981年12月期间入住库克县医院的所有镰状细胞贫血患者以及血红蛋白病门诊患者的血涂片。发现了9例红细胞脱逸情况。相关的临床病症包括充血性心力衰竭、急性病毒综合征、肺炎和转移性恶性肿瘤。一名患者在相隔一年的两次单独住院期间均出现了与充血性心力衰竭相关的短暂脱逸。脱逸是镰状细胞贫血中发生的红细胞破碎的一种短暂形式。其发病机制尚不清楚。局部循环淤滞和缺氧在镰状细胞贫血中诱导红细胞膜损伤的作用需要研究。
