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烟囱技术腔内动脉瘤封闭术后支架移植物几何形态变化的评估。

Assessment of changes in stent graft geometry after chimney endovascular aneurysm sealing.

机构信息

Department of Vascular Surgery, St Antonius Hospital, Nieuwegein, The Netherlands; Multimodality Medical Imaging M3i Group, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Department of Vascular Surgery, St Antonius Hospital, Nieuwegein, The Netherlands; Multimodality Medical Imaging M3i Group, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

出版信息

J Vasc Surg. 2019 Dec;70(6):1754-1764. doi: 10.1016/j.jvs.2019.02.058. Epub 2019 May 29.

Abstract

BACKGROUND

Chimney endovascular aneurysm sealing (ch-EVAS) could potentially minimize gutter-associated endoleaks in patients with juxtarenal abdominal aortic aneurysms resulting from the use of the conformable endobags surrounding the chimney stent grafts (ch-SGs). The aim of the present study was to quantify the (non)apposition of the endobags in the proximal aortic neck, migration of the endograft stent frames, and changes in geometry of the ch-SGs during the follow-up period.

METHODS

The prospective data from 20 patients undergoing elective ch-EVAS were retrospectively reviewed. The aortic anatomy was analyzed on preoperative and postoperative computed tomography scans. The (non)apposition of the endobags in the aortic neck, Nellix (Endologix, Irvine, Calif) stent frame migration, and chimney graft geometry and migration were assessed.

RESULTS

The median preoperative infrarenal neck length was 4.0 mm (interquartile range [IQR], 0-6.0 mm). The median seal length in the juxtarenal aortic neck at the first follow-up was 23.0 mm (IQR 18.0-30.8 mm). Five type IA endoleaks were identified on postoperative imaging; one at 1 month and four newly diagnosed at 1 year. Of these five type IA endoleaks, two were type Is1 (not extending into the aneurysm sac) and did not need reintervention and other three were type Is2 (extending into the aneurysm sac). One of these patients died of malignancy before reintervention could be performed. Bilateral ch-SG occlusions in one patient were documented at the 1-month follow-up (patient needed hemodialysis) and two patients with a new single ch-SG occlusion were found at the 1-year follow-up. No reinterventions were performed for the ch-SG occlusions. An occluded Nellix stent frame in one patient was treated with femorofemoral crossover bypass. Kaplan-Meier estimate of reintervention-free survival was 85.0% after 1 year. Migration ≥5 mm of the proximal end of the Nellix stent frames was observed in 20.0% of the patients, but no reintervention was performed at the 1-year follow-up. Imaging showed 20.1% of the available sealing surface was not used, and the nonapposition surface increased to 30.6% of the preoperative aortic neck surface at 1 year. Median migration was 3.5 mm (IQR, 2.4-5.0 mm) and 3.1 mm (IQR, 2.0-4.8 mm) for the left and right proximal end of the Nellix stent frames, respectively, and was 3.0 mm (IQR, 2.2-4.8 mm) for the proximal end of the ch-SGs at 1 year of follow-up.

CONCLUSIONS

Substantial distal migration of the Nellix endograft and positional changes of the ch-SGs in the juxtarenal aortic neck were observed at 1 year of follow-up, resulting in a 25.0% type IA endoleak rate, with three of these type IA endoleaks extending into the aneurysm sac. The reintervention-free survival rate was 85.0% at 1 year in this cohort of 20 patients. Careful follow-up after ch-EVAS is advised because changes are often subtle. The authors have stopped the ch-EVAS procedure so far. Long-term follow-up data on the stability of the Nellix endograft and the consequences of migration on ch-SGs is required before this technique should be used in clinical practice.

摘要

背景

chimney 血管内动脉瘤封闭术(ch-EVAS)可以最大限度地减少使用顺应性覆膜支架包裹 chimney 支架移植物(ch-SGs)导致的肾下腹主动脉瘤患者 gutter 相关内漏的发生。本研究的目的是定量分析近端主动脉颈内覆膜支架的贴合情况、移植物支架框架的迁移以及 ch-SGs 的几何形状在随访期间的变化。

方法

回顾性分析 20 例行选择性 ch-EVAS 的患者的前瞻性数据。对术前和术后 CT 扫描进行主动脉解剖分析。评估近端主动脉颈内覆膜支架的贴合情况、Nellix 支架框架的迁移以及 chimney 移植物的几何形状和迁移。

结果

术前肾下段颈长度中位数为 4.0mm(四分位距[IQR]:0-6.0mm)。首次随访时近段主动脉颈的中位封闭长度为 23.0mm(IQR:18.0-30.8mm)。术后影像学检查发现 5 例 I 型内漏;1 例在 1 个月时,4 例在 1 年时新诊断。这 5 例 I 型内漏中,2 例为 I 型 s1(未延伸至动脉瘤囊),无需再次干预,其他 3 例为 I 型 s2(延伸至动脉瘤囊)。其中 1 例患者在再次干预前死于恶性肿瘤。1 例患者在 1 个月随访时发现双侧 ch-SG 闭塞(患者需要血液透析),1 例患者在 1 年随访时发现 2 例新的单侧 ch-SG 闭塞。ch-SG 闭塞未进行再次干预。1 例Nellix 支架框架闭塞患者行股股旁路转流术治疗。1 年后,无再干预的Kaplan-Meier 估计生存率为 85.0%。20.0%的患者近端 Nellix 支架框架迁移≥5mm,但在 1 年随访时未进行再干预。影像学显示,20.1%的有效封闭面未被使用,1 年后,近端主动脉颈表面的不贴合面增加至 30.6%。Nellix 支架框架左右近端的中位迁移分别为 3.5mm(IQR:2.4-5.0mm)和 3.1mm(IQR:2.0-4.8mm),ch-SGs 的近端迁移为 3.0mm(IQR:2.2-4.8mm),随访 1 年。

结论

在 1 年的随访中,观察到 Nellix 移植物的远端明显迁移和 ch-SGs 在近段主动脉颈的位置变化,导致 25.0%的 I 型内漏发生率,其中 3 例 I 型内漏延伸至动脉瘤囊。20 例患者中有 85.0%在 1 年内无再干预生存率。因此,建议在 chimney 血管内动脉瘤封闭术后进行仔细随访,因为变化通常很细微。作者已经停止了 chimney 血管内动脉瘤封闭术的手术。在这项技术应用于临床实践之前,需要长期随访Nellix 移植物的稳定性和迁移对 ch-SGs 的影响的数据。

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