PostGraduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, CEP: 90050-170 Porto Alegre, RS, Brazil; Neuroendocrinology Center, Santa Casa de Porto Alegre/UFCSPA, Rua Professor Annes Dias, 295, CEP: 90020-090 Porto Alegre, RS, Brazil.
PostGraduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, CEP: 90050-170 Porto Alegre, RS, Brazil; Neuroendocrinology Center, Santa Casa de Porto Alegre/UFCSPA, Rua Professor Annes Dias, 295, CEP: 90020-090 Porto Alegre, RS, Brazil.
Ann Diagn Pathol. 2019 Aug;41:83-89. doi: 10.1016/j.anndiagpath.2019.04.016. Epub 2019 May 2.
Non-functioning pituitary adenomas (NFPA) are prevalent pituitary neoplasms. Because they do not present with hormonal hypersecretion, there is no marker that indicates regrowth or recurrence, as in other adenomas.
Evaluate the immunohistochemical expression of PTTG, CD105 and Ki-67 and their relationships with age, gender, invasiveness, hormonal expression and regrowth or recurrence in the follow-up of NFPA operated and not submitted to radiotherapy.
Included 56 patients submitted to transsphenoidal surgery. Clinical data were obtained from medical records. The invasion degree was obtained by Hardy's classification.
Mean age 55 ± 13.6 years, 62.5% men and 68% invasive. Lesion persistence was present in 62.2% and regrowth in 35.7%. The recurrence-free survival rate was 94.5%, 75.4% and 69.1% (1, 2 and 3 years). No patient presented recurrence. The PTTG was positive in 55.3%, with statistically significant relationship with invasiveness, age and female gender, without relation to regrowth. The microvascular density showed statistically significant relationship with male gender, negative correlation with PTTG (r = -0.434, p = 0.001), and no relation with invasiveness and regrowth. The Ki-67 showed statistically significant relationship with age, tendency towards regrowth (p = 0.054) and, with no relation to invasiveness.
It is suggested that PTTG can be used as a prognostic marker in NFPA.
无功能垂体腺瘤（NFPA）是常见的垂体肿瘤。由于它们不表现为激素分泌过多，因此没有像其他腺瘤那样表明复发或生长的标志物。
评估 PTTG、CD105 和 Ki-67 的免疫组织化学表达及其与年龄、性别、侵袭性、激素表达以及 NFPA 手术患者随访中的生长或复发的关系，这些患者未接受放疗。
纳入 56 例接受经蝶窦手术的患者。临床数据来自病历。侵袭程度采用 Hardy 分类法获得。
平均年龄 55±13.6 岁，男性占 62.5%，侵袭性占 68%。62.2%的患者存在病变残留，35.7%的患者存在生长。无复发生存率分别为 94.5%、75.4%和 69.1%（1、2 和 3 年）。无患者出现复发。PTTG 阳性率为 55.3%，与侵袭性、年龄和女性性别具有统计学显著关系，与生长无关系。微血管密度与性别具有统计学显著关系，与 PTTG 呈负相关（r=-0.434，p=0.001），与侵袭性和生长无关系。Ki-67 与年龄具有统计学显著关系，与生长呈趋势性相关（p=0.054），与侵袭性无关。
提示 PTTG 可作为 NFPA 的预后标志物。
