Diabetes Laboratory, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune-Satara Road, Pune, Maharashtra 411043, India.
Mother and Child Health Department, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune-Satara Road, Pune, Maharashtra 411043, India.
Cytokine. 2019 Sep;121:154735. doi: 10.1016/j.cyto.2019.154735. Epub 2019 May 30.
Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and glucose metabolism. Leptin is primarily involved in regulating food intake, body weight and energy homeostasis through neuroendocrine functions. Contemporary research suggests that leptin also influences insulin sensitivity and lipid metabolism. High leptin concentrations are directly associated with the obesity subsequent development of metabolic disease sequelae such as insulin resistance, type 2 diabetes and cardiovascular diseases. Elucidation of the mechanism of action of leptin would help to develop novel therapeutic approaches for there metabolic disorders like obesity and diabetes. This review provides an updated 'state-of-the-art' about the leptin and its role in the pathophysiology of metabolic syndrome at the molecular level.
代谢综合征对人类健康构成重大威胁，影响生活质量。脂肪组织是一种重要的器官，在代谢综合征的发病机制中起着关键作用。脂肪组织分泌的脂肪细胞因子在储存、食物摄入、能量消耗、脂质和葡萄糖代谢中起着关键作用。瘦素主要通过神经内分泌功能调节食物摄入、体重和能量平衡。现代研究表明，瘦素还影响胰岛素敏感性和脂质代谢。高浓度的瘦素与肥胖后代谢疾病的后遗症直接相关，如胰岛素抵抗、2 型糖尿病和心血管疾病。阐明瘦素的作用机制将有助于为肥胖和糖尿病等代谢紊乱开发新的治疗方法。这篇综述提供了关于瘦素及其在代谢综合征病理生理学中的分子水平作用的最新“现状”。
