Department of Ophthalmology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Curr Eye Res. 2019 Nov;44(11):1220-1225. doi: 10.1080/02713683.2019.1627462. Epub 2019 Jun 13.
: To determine the prevalence, clinical manifestations, and treatment outcomes of IgG4-related ophthalmic disease (IgG4-ROD) in previously diagnosed idiopathic orbital inflammation (IOI).: Thirty one surgically treated patients with IOI between 1990 and 2015 were divided into sclerosing (SIOI) and non-sclerosing (NSIOI) to identify IgG4-ROD. Preserved pathological specimens were immunostained for IgG4 cells. Changes in clinical features were evaluated before and after treatment.: Out of the 31 patients, 15 (48.4%) had IgG4-ROD, consisting of 7 of the 16 SIOI (43.8%) and 8 of the 15 NSIOI patients (53.3%). Among 15 patients with IgG4-ROD, 4 (26.7%) achieved complete remission, which was significantly less than among IgG4-unrelated patients (11/16, 68.8%, = .03). Furthermore, 3 out of 15 IgG4-ROD patients (20%) experienced recurrence, all of whom had SIOI, compared to 0% among IgG4-unrelated patients ( = .1).: IgG4-ROD is common among previously identified IOI in our study. Treatment response is modest in IgG4-ROD patients.
为了确定在先前诊断为特发性眼眶炎症（IOI）的患者中 IgG4 相关眼病（IgG4-ROD）的患病率、临床表现和治疗结果：在 1990 年至 2015 年间，对 31 例接受手术治疗的 IOI 患者进行了分类，分为硬化性（SIOI）和非硬化性（NSIOI），以确定 IgG4-ROD。保留的病理标本进行 IgG4 细胞免疫染色。评估治疗前后临床特征的变化。：在 31 例患者中，有 15 例（48.4%）患有 IgG4-ROD，其中 16 例 SIOI 中有 7 例（43.8%），15 例 NSIOI 中有 8 例（53.3%）。在 15 例 IgG4-ROD 患者中，4 例（26.7%）达到完全缓解，明显低于 IgG4 无关患者（11/16，68.8%， = 0.03）。此外，在 15 例 IgG4-ROD 患者中有 3 例（20%）出现复发，均为 SIOI，而 IgG4 无关患者中无一例（ = 0.1）。：在我们的研究中，在先前确定的 IOI 中 IgG4-ROD 很常见。IgG4-ROD 患者的治疗反应适中。
