Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ONT, M5G 1M1, Canada.
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ONT, M5G 1M1, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ONT, M5S 1A8, Canada.
Trends Genet. 2019 Aug;35(8):589-600. doi: 10.1016/j.tig.2019.05.001. Epub 2019 May 31.
Genome expression and stability are dependent on biological processes that control repetitive DNA sequences and nuclear compartmentalization. The phase separation of macromolecules has recently emerged as a major player in the control of biological pathways. Here, we summarize recent studies that collectively reveal intersections between phase separation, repetitive DNA elements, and nuclear compartments. These intersections modulate fundamental processes, including gene expression, DNA repair, and cellular lifespan, in the context of health and diseases such as cancer and neurodegeneration.
基因组的表达和稳定性依赖于控制重复 DNA 序列和核区室化的生物过程。大分子的相分离最近成为控制生物途径的主要参与者。在这里，我们总结了最近的研究，这些研究共同揭示了相分离、重复 DNA 元件和核区室之间的交叉点。这些交叉点在健康和疾病（如癌症和神经退行性疾病）的背景下调节着包括基因表达、DNA 修复和细胞寿命在内的基本过程。
