水通道蛋白4的脑脊液水平：关于神经胶质淋巴系统参与神经退行性疾病的新窗口？

Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

作者信息

Arighi Andrea, Di Cristofori Andrea, Fenoglio Chiara, Borsa Stefano, D'Anca Marianna, Fumagalli Giorgio Giulio, Locatelli Marco, Carrabba Giorgio, Pietroboni Anna Margherita, Ghezzi Laura, Carandini Tiziana, Colombi Annalisa, Scarioni Marta, De Riz Milena Alessandra, Serpente Maria, Rampini Paolo Maria, Scarpini Elio, Galimberti Daniela

机构信息

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, UOSD Neurologia - Malattie Neurodegenerative, Milan, Italy.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

出版信息

J Alzheimers Dis. 2019;69(3):663-669. doi: 10.3233/JAD-190119.

DOI:10.3233/JAD-190119

PMID:31156164

Abstract

Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.

摘要

水通道蛋白4（AQP4）是一种位于星形胶质细胞足突的水通道蛋白，在类淋巴系统中发挥作用，类淋巴系统是一种高度有组织的液体运输途径，似乎与阿尔茨海默病（AD）和正常压力脑积水（NPH）的病理生理学有关。测定了11例AD患者、10例NPH患者和9例对照者的脑脊液（CSF）AQP4水平。我们发现AD患者的AQP4显著降低，NPH患者有降低趋势，且AQP4与CSF淀粉样β蛋白水平之间存在相关性。本研究表明AQP4和类淋巴系统在神经退行性疾病病理生理学中的潜在作用。