Closset M, Hecq J D, Gonzalez E, Bihin B, Jamart J, Galanti L
Medical Laboratory, CHU Dinant Godinne | UCL Namur, Yvoir, Belgium.
Department of Pharmacy, CHU Dinant Godinne | UCL Namur, Yvoir, Belgium.
Eur J Hosp Pharm. 2017 Jul;24(4):230-234. doi: 10.1136/ejhpharm-2016-001045. Epub 2016 Oct 12.
An international alert from Becton Dickinson (BD) has noted the possibility of interaction between several molecules and some syringes. The Centralized IntraVenous Additives Service of the institution was using 3 mL BD syringes to store ketamine HCl. This study evaluated the interaction between ketamine and these syringes.
A batch of BD syringes produced in Europe and left in quarantine from the day of the international alert has been tested at 22, 29, 36, 43 and 50 days of storage at room temperature. At each time, the pH of the solutions was measured. The solutions were inspected visually and by microscope, and spectrophotometric measurements were performed. The concentrations were measured by a validated ultra-high-performance liquid chromatography-diode array detector.
Neither physical change nor pH modification was observed during the study. According to a lower limit of the 95% unilateral CI on the mean >90% of the theoretical concentration, the solutions remain stable for at least 50 days.
In our study conditions, ketamine can be stored for at least 50 days without risk of sorption with syringes.
贝克顿·迪金森公司（BD）发布的一份国际警报指出，几种分子与某些注射器之间可能存在相互作用。该机构的集中式静脉内添加剂服务部门使用3毫升BD注射器储存盐酸氯胺酮。本研究评估了氯胺酮与这些注射器之间的相互作用。
一批在欧洲生产且自国际警报之日起处于隔离状态的BD注射器，在室温下储存22、29、36、43和50天时进行了测试。每次都测量溶液的pH值。通过目视和显微镜检查溶液，并进行分光光度测量。浓度通过经过验证的超高效液相色谱-二极管阵列检测器进行测量。
研究期间未观察到物理变化或pH值改变。根据平均理论浓度的95%单侧置信区间下限>90%，溶液至少在50天内保持稳定。
在我们的研究条件下，氯胺酮可以储存至少50天，而不存在与注射器吸附的风险。
