Department of Medicine, University of Illinois at Chicago, IL 60612, USA.
Department of Biochemistry & Molecular Genetics, University of Illinois at Chicago, IL 60612, USA.
Biomark Med. 2019 Jun;13(9):715-724. doi: 10.2217/bmm-2018-0280. Epub 2019 Jun 3.
Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Sputum induction was performed in patients with asthma and in healthy controls. Sputum analysis revealed higher (p < 0.001) levels of CLC/Gal-10 and MBP-1 in asthmatics versus healthy controls. CLC/Gal-10 levels were highly correlated (r = 0.74; p < 0.001) with sputum eosinophils; MBP-1 approached significance (r = 0.44; p = 0.07). Increased CLC/Gal-10 and MBP-1 levels in the sputum were strongly correlated with sputum eosinophils in patients with asthma. CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.
嗜酸性粒细胞性哮喘与更多的恶化和治疗反应差异有关。本研究旨在评估 CLC/Gal-10 和 MBP-1 是否是哮喘中嗜酸性炎症的替代生物标志物。对哮喘患者和健康对照者进行了痰诱导。痰分析显示，哮喘患者的 CLC/Gal-10 和 MBP-1 水平明显高于健康对照组（p < 0.001）。CLC/Gal-10 水平与痰中嗜酸性粒细胞高度相关（r = 0.74；p < 0.001）；MBP-1 接近显著相关（r = 0.44；p = 0.07）。哮喘患者痰中 CLC/Gal-10 和 MBP-1 水平的增加与痰中嗜酸性粒细胞强烈相关。CLC/Gal-10 和 MBP-1 可能是区分哮喘嗜酸性气道炎症的有用生物标志物。
