视网膜静脉阻塞患者接受抗血管内皮生长因子治疗后，视网膜缺血对视功能和解剖结构结局的影响。

IMPACT OF RETINAL ISCHEMIA ON FUNCTIONAL AND ANATOMICAL OUTCOMES AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN PATIENTS WITH RETINAL VEIN OCCLUSION.

机构信息

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

The Department of Anatomy, Collage of Medicine-Rabigh Branch, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Retina. 2020 Jun;40(6):1098-1109. doi: 10.1097/IAE.0000000000002571.

DOI:10.1097/IAE.0000000000002571

PMID:31157714

Abstract

PURPOSE

To compare the impact of the classification of retinal vein occlusion (RVO) into ischemic or nonischemic forms on outcomes after anti-vascular endothelial growth factor therapy.

METHODS

Retrospective review of consecutive patients with RVO evaluated at the Belfast Health and Social Care Trust between July 1, 2014, and December 31, 2015. Outcomes, including gain of ≥10 and ≥15 letters at 12 months, mean change in best-corrected visual acuity from baseline to 12 months, resolution of macular edema at 12 months, and development of neovascular complications and epiretinal membrane after anti-vascular endothelial growth factor therapy, were compared between ischemic and nonischemic eyes using regression models.

RESULTS

One hundred and seventeen eyes (115 patients), 58 with central RVO and 59 with branch RVO, were included. A greater proportion of eyes with ischemic branch RVO gained ≥10 and ≥15 letters at 12 months than those with nonischemic branch RVO (P = 0.005 and P = 0.016, respectively). No statistically significant differences in visual outcomes were observed between ischemic and nonischemic central RVO. Retinal vein occlusion classification was not associated with anatomical outcomes after treatment.

CONCLUSION

Findings support the use of anti-vascular endothelial growth factors in ischemic and nonischemic forms of RVO.

摘要

目的

比较视网膜静脉阻塞（RVO）分类为缺血性或非缺血性形式对血管内皮生长因子治疗后结果的影响。

方法

回顾性分析 2014 年 7 月 1 日至 2015 年 12 月 31 日期间在贝尔法斯特健康和社会保健信托接受评估的连续 RVO 患者。使用回归模型比较缺血性和非缺血性眼在 12 个月时≥10 和≥15 个字母的增益、从基线到 12 个月时最佳矫正视力的平均变化、12 个月时黄斑水肿的消退以及血管内皮生长因子治疗后新生血管并发症和视网膜内膜的发展等结局。

结果

共纳入 117 只眼（115 例患者），其中 58 只眼中央 RVO，59 只眼中 RVO。与非缺血性分支 RVO 相比，缺血性分支 RVO 在 12 个月时获得≥10 和≥15 个字母的眼比例更高（P = 0.005 和 P = 0.016）。缺血性和非缺血性中央 RVO 的视力结果无统计学差异。视网膜静脉闭塞分类与治疗后的解剖学结果无关。