1Gastroenterology, Nanjing Jiangbei People's Hospital, Nanjing, China.
2Infectious Diseases Section, Nanjing Jiangbei People's Hospital, Nanjing, China.
Viral Immunol. 2019 Jul/Aug;32(6):263-268. doi: 10.1089/vim.2018.0131. Epub 2019 Jun 3.
As the main effector cells of innate immunity, nature killer (NK) cells play important roles in preventing hepatitis B virus (HBV) infection. This study aims to investigate the correlation between NK cells and different clinical stages of chronic HBV infection and interferon- (IFN-) therapy. Two hundred ninety-five patients diagnosed with chronic hepatitis B (CHB) infection and selected 50 healthy adults were enrolled in this study, the frequency of CD3CD56 cells in peripheral blood were measured and analyzed. The level of NK cells was decreased in hepatitis B-associated liver cirrhosis significantly and had no changes in CHB or hepatocellular carcinoma, while the frequency of NK cells gradually decreased from the baseline to week 24 and then increased since week 24-48 in CHB with IFN- treatment. NK cells played an important role in the process of HBV progression and IFN- therapy.
作为天然免疫的主要效应细胞，自然杀伤 (NK) 细胞在预防乙型肝炎病毒 (HBV) 感染中发挥着重要作用。本研究旨在探讨 NK 细胞与慢性乙型肝炎病毒感染不同临床阶段和干扰素- (IFN-) 治疗的相关性。本研究纳入了 295 例诊断为慢性乙型肝炎 (CHB) 感染的患者和 50 名健康成年人，测量并分析了外周血中 CD3CD56 细胞的频率。乙型肝炎相关肝硬化患者的 NK 细胞水平显著降低，而 CHB 或肝细胞癌患者的 NK 细胞水平没有变化，而接受 IFN-治疗的 CHB 患者的 NK 细胞频率从基线逐渐下降至第 24 周，然后从第 24-48 周开始升高。NK 细胞在 HBV 进展和 IFN-治疗过程中发挥着重要作用。
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