Vermesh M, Kletzky O A
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033.
J Clin Endocrinol Metab. 1987 Oct;65(4):653-8. doi: 10.1210/jcem-65-4-653.
The precise patterns of LH, FSH, and PRL secretion and their correlation with estradiol (E2) and progesterone (P) secretion during the entire luteal phase have not been elucidated. To analyze in detail the secretory patterns of these hormones we performed 29 consecutive studies in 5 healthy, regularly menstruating women throughout their luteal phase [days 0 (ovulation), 2, 6, 10, and 14] and subsequent early follicular phase (day 2F). During each study plasma LH, FSH, PRL, E2, and P were measured at 10-min intervals for 6 h. Both plasma LH concentrations and LH pulse frequency declined from days 0 to 10 and increased thereafter, whereas LH pulse amplitude continued to decline throughout the luteal and early follicular phases. Plasma FSH concentrations followed a pattern similar to that of LH; however, there was a larger increase in the FSH level on days 14 and 2F. Plasma PRL levels declined initially on day 2 and again on day 14. Regression analysis indicated a positive correlation between LH concentrations and LH pulse frequency (r = 0.715; P less than 0.001) and between PRL and E2 concentrations (r = 0.528; P less than 0.01). A negative correlation was found between plasma P concentrations and both LH concentrations (r = -0.521; P less than 0.01) and LH pulse frequency (r = -0.633; P less than 0.001) and between plasma E2 and FSH concentrations (r = -0.762; P less than 0.001). Thirty-six (65%) PRL pulses and only 11 (39%) FSH pulses coincided with LH pulses. There was no clear pulsatile pattern of secretion of either E2 or P. We conclude that 1) the plasma LH, FSH, PRL, E2, and P concentrations vary markedly throughout the luteal phase; 2) the plasma LH level is largely dependent on the frequency of LH pulses; 3) plasma P decreases plasma LH by reducing the frequency of LH pulses; 4) the remarkable synchrony between PRL pulses and LH pulses implies that their secretion may be regulated by a common neuroendocrine mechanism; and 5) the preferential increase in FSH during the late luteal phase may play an important role in follicular recruitment for the subsequent cycle.
在整个黄体期，促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素（PRL）的精确分泌模式及其与雌二醇（E2）和孕酮（P）分泌的相关性尚未阐明。为了详细分析这些激素的分泌模式，我们对5名健康、月经周期规律的女性在整个黄体期[第0天（排卵）、第2天、第6天、第10天和第14天]以及随后的卵泡早期（第2F天）进行了29项连续研究。在每项研究中，每隔10分钟测量一次血浆LH、FSH、PRL、E2和P，共测量6小时。从第0天到第10天，血浆LH浓度和LH脉冲频率均下降，此后升高，而LH脉冲幅度在整个黄体期和卵泡早期持续下降。血浆FSH浓度的变化模式与LH相似；然而，在第14天和第2F天，FSH水平有较大幅度的升高。血浆PRL水平在第2天最初下降，在第14天再次下降。回归分析表明，LH浓度与LH脉冲频率之间呈正相关（r = 0.715；P < 0.001），PRL与E2浓度之间也呈正相关（r = 0.528；P < 0.01）。发现血浆P浓度与LH浓度（r = -0.521；P < 0.01）和LH脉冲频率（r = -0.633；P < 0.001）之间呈负相关，血浆E2与FSH浓度之间也呈负相关（r = -0.762；P < 0.001）。36次（65%）PRL脉冲和仅11次（39%）FSH脉冲与LH脉冲同时出现。E2或P均没有明显的脉冲式分泌模式。我们得出以下结论：1）在整个黄体期，血浆LH、FSH、PRL、E2和P浓度有显著变化；2）血浆LH水平很大程度上取决于LH脉冲频率；3）血浆P通过降低LH脉冲频率来降低血浆LH；4）PRL脉冲与LH脉冲之间显著的同步性意味着它们的分泌可能受共同的神经内分泌机制调节；以及5）黄体后期FSH的优先升高可能在随后周期的卵泡募集过程中起重要作用。
