Medical Genomics Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
Altius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
Bioinformatics. 2019 Nov 1;35(22):4767-4769. doi: 10.1093/bioinformatics/btz456.
The Illumina Infinium EPIC BeadChip is a new high-throughput array for DNA methylation analysis, extending the earlier 450k array by over 400 000 new sites. Previously, a method named eFORGE was developed to provide insights into cell type-specific and cell-composition effects for 450k data. Here, we present a significantly updated and improved version of eFORGE that can analyze both EPIC and 450k array data. New features include analysis of chromatin states, transcription factor motifs and DNase I footprints, providing tools for epigenome-wide association study interpretation and epigenome editing.
eFORGE v2.0 is implemented as a web tool available from https://eforge.altiusinstitute.org and https://eforge-tf.altiusinstitute.org/.
Supplementary data are available at Bioinformatics online.
Illumina Infinium EPIC BeadChip 是一种新的高通量 DNA 甲基化分析芯片，它通过超过 40 万个新的位点扩展了早期的 450k 芯片。此前，开发了一种名为 eFORGE 的方法，用于深入了解 450k 数据的细胞类型特异性和细胞组成效应。在这里，我们提出了一个经过显著更新和改进的 eFORGE 版本，它可以分析 EPIC 和 450k 阵列数据。新功能包括染色质状态、转录因子基序和 DNase I 足迹分析，为全基因组关联研究解释和表观基因组编辑提供了工具。
eFORGE v2.0 作为一个网络工具，可从 https://eforge.altiusinstitute.org 和 https://eforge-tf.altiusinstitute.org/ 获取。
补充数据可在生物信息学在线获得。
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