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胶原海绵中庆大霉素体外抗在羟基磷灰石表面形成的细菌生物膜的效果。

In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface.

机构信息

Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Wrocław, Poland.

Centre for Advanced Manufacturing Technologies (CAMT/FPC), Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland.

出版信息

PLoS One. 2019 Jun 4;14(6):e0217769. doi: 10.1371/journal.pone.0217769. eCollection 2019.

DOI:10.1371/journal.pone.0217769
PMID:31163049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6548372/
Abstract

Biofilm-related infections of bones pose a significant therapeutic issue. In this article we present in vitro results of the efficacy of gentamicin released from a collagen sponge carrier against Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae biofilms preformed on hydroxyapatite surface. The results indicate that high local concentrations of gentamicin released from a sponge eradicate the biofilm formed not only by gentamicin-sensitive strains but, to some extent, also by those that display a resistance pattern in routine diagnostics. The data presented in this paper is of high clinical translational value and may find application in the treatment of bone infections.

摘要

骨骼生物膜相关感染是一个重大的治疗难题。本文介绍了庆大霉素从胶原海绵载体中释放出来对金黄色葡萄球菌、铜绿假单胞菌和肺炎克雷伯菌在羟基磷灰石表面形成的生物膜的体外疗效的实验结果。结果表明，从海绵中释放的高浓度庆大霉素不仅可以消除常规诊断中显示耐药模式的庆大霉素敏感菌株形成的生物膜，也可以消除生物膜。本文所提供的数据具有很高的临床转化价值，可能在治疗骨感染方面有应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/f7c7c70cbc47/pone.0217769.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/f51f049a1f6c/pone.0217769.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/bda7fdc78e64/pone.0217769.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/2412cc43b580/pone.0217769.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/9adf479466f0/pone.0217769.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/18c98e5ee8fb/pone.0217769.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/f7c7c70cbc47/pone.0217769.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/f51f049a1f6c/pone.0217769.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/bda7fdc78e64/pone.0217769.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/2412cc43b580/pone.0217769.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/9adf479466f0/pone.0217769.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/18c98e5ee8fb/pone.0217769.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4188/6548372/f7c7c70cbc47/pone.0217769.g006.jpg

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