Hashimoto Yu, Ueno Kimihiko, Akita Masayuki, Tsugawa Daisuke, Awazu Masahide, Mukubou Hideyo, Komatsu Shohei, Terai Sachio, Tanaka Motofumi, Kido Masahiro, Toyama Hirochika, Ajiki Tetsuo, Fukumoto Takumi
Dept. of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2019 Apr;46(4):775-777.
A 47-year-old woman who had unresectable locally advanced gallbladder cancer(GBC)accompanied with liverinvasion, duodenum invasion, transverse colon invasion, and surrounding lymphatic metastasis received 5 courses of chemotherapy with gemcitabine plus cisplatin. Afterthe chemotherapy, imaging showed down-staging of the GBC, indicating tumor shrinkage. The initial laparoscopic examination revealed no peritoneal seeding or distant metastasis. Subsequently, we performed cholecystectomy with a partial hepatectomy at the gallbladder bed. Malignant findings were not observed in the histopathological examination and the pathological diagnosis was CR with pT0N0M0, Stage 0. The patient was discharged on day 11 after the operation. There has been no recurrence at 14 months after surgery. Although the prognosis of advanced GBC with local invasion is generally poor, chemotherapy might be an effective treatment for patients with initially unresectable locally advanced gallbladder carcinoma.
一名47岁女性，患有无法切除的局部晚期胆囊癌（GBC），伴有肝脏侵犯、十二指肠侵犯、横结肠侵犯及周围淋巴结转移，接受了5个疗程的吉西他滨联合顺铂化疗。化疗后，影像学检查显示GBC分期降低，提示肿瘤缩小。最初的腹腔镜检查未发现腹膜种植或远处转移。随后，我们在胆囊床行胆囊切除术并部分肝切除术。组织病理学检查未发现恶性病变，病理诊断为CR，pT0N0M0，0期。患者术后第11天出院。术后14个月无复发。尽管局部侵犯的晚期GBC预后通常较差，但化疗可能是初始无法切除的局部晚期胆囊癌患者的有效治疗方法。
