The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, PR China.
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, PR China.
Biomark Med. 2019 Jul;13(10):821-829. doi: 10.2217/bmm-2019-0004. Epub 2019 Jun 5.
To investigate the relationship between urinary pH (UpH) and clinical outcome in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Data of 2081 patients with ST-segment elevation myocardial infarction were analyzed, including UpH. Patients were divided into UpH <6.0, 6.0≤ UpH <7.0 and UpH ≥7.0 based on UpH level. The primary outcome was in-hospital all-cause mortality and major adverse clinical events. The incidence of in-hospital clinical outcomes was significantly higher in low UpH group. Multivariate analysis found low UpH (<6.0) was an independent predictor of in-hospital all-cause mortality (OR: 2.85) and major adverse clinical events (OR: 2.39). A Kaplan-Meier analysis showed long-term all-cause mortality was also significantly higher in low UpH group. The multivariate cox analysis demonstrated that low UpH was an independent predictor of long-term all-cause mortality (HR: 2.57). Low UpH is a simple, accessible and powerful marker of poor clinical outcomes in such patients.
探讨经皮冠状动脉介入治疗的 ST 段抬高型心肌梗死患者尿 pH 值（UpH）与临床结局的关系。分析了 2081 例 ST 段抬高型心肌梗死患者的数据，包括 UpH。根据 UpH 水平将患者分为 UpH<6.0、6.0≤UpH<7.0 和 UpH≥7.0 组。主要结局为院内全因死亡率和主要不良临床事件。低 UpH 组院内临床结局的发生率显著更高。多变量分析发现低 UpH(<6.0)是院内全因死亡率（OR：2.85）和主要不良临床事件（OR：2.39）的独立预测因子。Kaplan-Meier 分析显示低 UpH 组的长期全因死亡率也显著更高。多变量 Cox 分析表明低 UpH 是长期全因死亡率的独立预测因子（HR：2.57）。低 UpH 是此类患者临床结局不良的简单、可及且有力的标志物。
