腰椎引流治疗 HIV 阴性隐球菌性脑膜炎难治性颅内高压。
Lumbar drainage for the treatment of refractory intracranial hypertension in HIV-negative cryptococcal meningitis.
机构信息
Department of Internal Neurology, Jiangxi Chest Hospital, Jiangxi 330000, PR China.
Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
出版信息
Future Microbiol. 2019 Jul;14:859-866. doi: 10.2217/fmb-2019-0084. Epub 2019 Jun 5.
This study aims to evaluate lumbar drainage (LD) for controlling refractory intracranial hypertension among non-HIV cryptococcal meningitis patients. A case-control study was designed to compare LD (case) with repeated lumbar puncture (control). Both LD and repeated lumbar puncture can efficiently control refractory intracranial hypertension. LD group showed better clinical symptom remission, such as lower rate of headache, vision disorders, signs of meningeal irritation and conscious disturbance, than control group. LD group was reported with higher intracranial pressure reduction (173.75 ± 17.72 mmHO) than those among control group (113.50 ± 14.94 mmHO; p < 0.05). LD is an effective and safe alternative to control refractory intracranial hypertension in HIV-negative cryptococcal meningitis patients.
本研究旨在评估腰椎引流（LD）在控制非 HIV 隐球菌性脑膜炎患者难治性颅内高压中的作用。设计了一项病例对照研究，比较 LD（病例组）与反复腰椎穿刺（对照组）。LD 和反复腰椎穿刺均能有效控制难治性颅内高压。LD 组的临床症状缓解更好，如头痛、视力障碍、脑膜刺激征和意识障碍的发生率较低，优于对照组。LD 组颅内压降低更明显（173.75±17.72mmHg），明显优于对照组（113.50±14.94mmHg；p<0.05）。LD 是控制 HIV 阴性隐球菌性脑膜炎患者难治性颅内高压的一种有效且安全的替代方法。
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