血小板与淋巴细胞比值及中性粒细胞与淋巴细胞比值是重症监护人群死亡率的有力预测指标。
Platelet to lymphocyte and neutrophil to lymphocyte ratios as strong predictors of mortality in intensive care population.
作者信息
Karagoz Ibrahim, Yoldas Hamit
机构信息
Training and Research Hospital, Department of Anesthesiology and Reanimation, Bolu, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2019 Jun 3;65(5):633-636. doi: 10.1590/1806-9282.65.5.633.
OBJECTIVE
Patients in intensive care units (ICU) have greater morbidity and mortality. We aimed to study neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in the ICU population.
METHODS
Medical and laboratory data of patients treated in ICU were retrospectively analyzed. Patients were divided into deceased and survived groups.
RESULTS
The NLR of survived and deceased groups were 3.6 (0.2-31) and 9.5 (1-40), respectively (p<0.001). The PLR of the survived group (111 [16-537]) was significantly lower than the PLR of the deceased (209 [52-1143]), (p<0.001). An NLR higher than 4.9 had 84% sensitivity and 67% specificity is selecting deceased patients (AUC:0.80, p<0.001). A PLR higher than 112 had 83% sensitivity and 52% specificity in predicting deadly cases (AUC:0.76, p<0.001). Both PLR and NLR were significantly and positively correlated with c reactive protein levels.
CONCLUSION
We suggest that physicians should pay particular attention to the treatment of patients in ICU with elevated NLR and PLR.
目的
重症监护病房（ICU）患者的发病率和死亡率更高。我们旨在研究ICU患者的中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）。
方法
对在ICU接受治疗的患者的医疗和实验室数据进行回顾性分析。将患者分为死亡组和存活组。
结果
存活组和死亡组的NLR分别为3.6（0.2 - 31）和9.5（1 - 40）（p<0.001）。存活组的PLR（111 [16 - 537]）显著低于死亡组（209 [52 - 1143]）（p<0.001）。NLR高于4.9在选择死亡患者时具有84%的敏感性和67%的特异性（曲线下面积：0.80，p<0.001）。PLR高于112在预测致命病例时具有83%的敏感性和52%的特异性（曲线下面积：0.76，p<0.001）。PLR和NLR均与C反应蛋白水平显著正相关。
结论
我们建议医生应特别关注NLR和PLR升高的ICU患者的治疗。
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