Division of Pulmonary and Critical Care Medicine, 12297NYU School of Medicine, New York, NY, USA.
12297VA New York Harbor Healthcare System, New York, NY, USA.
J Intensive Care Med. 2020 Nov;35(11):1356-1362. doi: 10.1177/0885066619855000. Epub 2019 Jun 5.
Aggressive fluid resuscitation has become standard of care for hypotensive patients with sepsis. However, sepsis is a syndrome that occurs in patients with diverse underlying physiology and a one-size-fits-all approach to fluid administration seems misguided. To individualize fluid management, several methods to assess fluid responsiveness have been validated, but even in fluid responsive patients, fluid administration may still be harmful and lead to pulmonary edema. Hence, to individualize fluid management, in addition to fluid responsiveness, fluid tolerance needs to be assessed. This article examines whether lung ultrasound can be useful to detect excess extravascular lung water (EVLW) and thus assess fluid tolerance. The physiology of EVLW and the principles of lung ultrasound are briefly described. Articles examining the correlation between EVLW and lung ultrasound findings in various clinical settings are carefully reviewed. Overall, lung ultrasound has been found to be an excellent tool to detect EVLW, but large outcome studies investigating lung ultrasound-guided fluid management are still lacking.
积极的液体复苏已经成为感染性休克低血压患者的标准治疗方法。然而,感染性休克是一种发生在具有不同潜在生理状态的患者中的综合征,采用一刀切的液体管理方法似乎是有误导性的。为了实现个体化液体管理,已经验证了几种评估液体反应性的方法,但即使在液体反应性患者中,液体的给予仍然可能是有害的,并导致肺水肿。因此,为了实现个体化液体管理,除了液体反应性外,还需要评估液体耐受性。本文探讨了肺超声是否可以用于检测过多的肺外血管内水(EVLW),从而评估液体耐受性。简要描述了 EVLW 的生理学和肺超声的原理。仔细回顾了检查各种临床情况下 EVLW 与肺超声表现之间相关性的文章。总的来说,肺超声已被发现是一种很好的检测 EVLW 的工具,但仍缺乏针对肺超声指导的液体管理的大型结局研究。