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椎间盘突出所致马尾综合征:长期功能预后

Cauda equina syndrome due to disk herniation: Long-term functional prognosis.

作者信息

Delgado-López Pedro David, Martín-Alonso Javier, Martín-Velasco Vicente, Castilla-Díez José Manuel, Galacho-Harriero Ana, Ortega-Cubero Sara, Rodríguez-Salazar Antonio

机构信息

Servicio de Neurocirugía, Hospital Universitario de Burgos, Spain.

Servicio de Neurocirugía, Hospital Universitario de Burgos, Spain.

出版信息

Neurocirugia (Engl Ed). 2019 Nov-Dec;30(6):278-287. doi: 10.1016/j.neucir.2019.05.002. Epub 2019 Jun 2.

Abstract

OBJECTIVE

Cauda equina syndrome (CES) caused by lumbar disk extrusion is classically considered an indication of urgent surgery. CES can be subdivided into CESI (incomplete CES) and CESR (complete CES with urinary retention and incontinence). This paper evaluates the long-term functional outcome of a CES cohort operated on due to disk herniation.

METHODS

Single-center retrospective observational study. CES patients due to disk herniation that underwent surgery between 2000 and 2016 were included in the study. Demographic data, time intervals to diagnosis and surgery, preoperative neurologic status and outcome at the end of follow up were recorded.

RESULTS

Twenty-two patients were included (median age 44 years). Eight patients were CESR and 14 CESI. Median time from symptom onset to diagnosis was 78h (range, 12-720h), and from diagnosis to surgery 24h (range, 5-120h). Median follow up was 75 months (range, 20-195 months). At the end of follow up, in the CESR group (median time from diagnosis to surgery, 23h) only pain significantly improved after surgery (p=0.007). In the CESI group (median time from diagnosis to surgery 23h) low back pain, sciatica and urinary sphincter function significantly improved (p<0.001). There were no significant differences between early (<48h) operation (n=4) and late (n=18) in terms of sphincter recovery (Fisher's Exact Test, p=0.076).

CONCLUSION

Pain associated to CES improved both in the CESI and CESR groups. However, urinary sphincter impairment significantly improved only in the CESI group. No significant differences were found regarding long-term functional outcome between early and late surgery.

摘要

目的

腰椎间盘突出所致马尾神经综合征(CES)传统上被视为紧急手术指征。CES可细分为CESI(不完全性CES)和CESR(伴有尿潴留和尿失禁的完全性CES)。本文评估了因椎间盘突出接受手术的CES队列的长期功能结局。

方法

单中心回顾性观察研究。纳入2000年至2016年间因椎间盘突出接受手术的CES患者。记录人口统计学数据、诊断和手术的时间间隔、术前神经状态及随访结束时的结局。

结果

纳入22例患者(中位年龄44岁)。8例为CESR,14例为CESI。从症状出现到诊断的中位时间为78小时(范围12 - 720小时),从诊断到手术的中位时间为24小时(范围5 - 120小时)。中位随访时间为75个月(范围20 - 195个月)。随访结束时,在CESR组(从诊断到手术的中位时间为23小时),术后仅疼痛有显著改善(p = 0.007)。在CESI组(从诊断到手术的中位时间为23小时),腰痛、坐骨神经痛和尿道括约肌功能有显著改善(p < 0.001)。早期(<48小时)手术(n = 4)和晚期手术(n = 18)在括约肌恢复方面无显著差异(Fisher精确检验,p = 0.076)。

结论

CESI组和CESR组与CES相关的疼痛均有改善。然而,仅CESI组尿道括约肌功能障碍有显著改善。早期和晚期手术在长期功能结局方面未发现显著差异。

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