a Department of Pharmacy, Xuanwu Hospital, The First Clinical Medical College of Capital Medical University , Beijing , China.
b National Clinical Research Center for Geriatric Disorders , Beijing , China.
Expert Opin Drug Saf. 2019 Sep;18(9):853-859. doi: 10.1080/14740338.2019.1629416. Epub 2019 Jun 23.
: There is a lack of direct evidence for the management of perioperative medications in elderly patients. Therefore, the authors aimed to develop a list of high-risk medications for the elderly population in China to provide indicators for clinicians to identify medication-related factors contributing to potential adverse events during the perioperative period. : The initial list of high-risk perioperative medications was developed by studying all the publications that described specific high-risk medications and their risk profiles in the elderly. Delphi consultations were performed to form a consensus among the group of experts and the list was finalized. : The expert panel consisted of 36 experts from 29 tertiary hospitals and 18 provinces or municipalities. The consensus was reached after two Delphi rounds. Finally, a total of 86 medications of 13 medication classes and 120 screening items were included in the final list, along with perioperative risk profiles and risk aversion recommendations for each drug. : This is the first study to establish a high-risk perioperative medication list in China, which can be used as a reference for intervention and evaluation of perioperative medications for the elderly population.
: 由于缺乏老年患者围手术期药物管理的直接证据，因此本研究旨在制定一份中国老年人群高危药物清单，为临床医生识别与围手术期潜在不良事件相关的药物因素提供指标。: 通过研究所有描述老年人群特定高危药物及其风险特征的出版物，制定了初始的围手术期高危药物清单。采用德尔菲法咨询专家组意见，达成共识并最终确定清单。: 专家组由来自 29 家三级医院和 18 个省、直辖市的 36 名专家组成。经过两轮德尔菲法咨询，最终达成共识。最终，该清单共纳入了 13 类药物 86 种药物和 120 项筛选项目，并附有每种药物的围手术期风险特征和风险规避建议。: 这是中国首次建立围手术期高危药物清单的研究，可作为干预和评估老年人群围手术期药物的参考。
