Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis. 2019 Sep 13;220(8):1276-1280. doi: 10.1093/infdis/jiz295.
Human infections caused by avian influenza A(H7N9) viruses have raised concerns of a pandemic. The capability of the current stockpiled A(H7N9) vaccines to induce cross-protective, nonneutralizing functional antibodies against antigenically drifted A(H7N9) viruses has not been evaluated before. Here we show that vaccination with either MF59- or AS03-adjuvanted inactivated A(H7N9) vaccines elicited robust, cross-reactive antibody-dependent cell-mediated cytotoxicity-mediating and neuraminidase-inhibiting functional antibodies against the antigenically drifted A(H7N9) viruses that emerged recently during the fifth-wave outbreak in China, including a highly pathogenic A(H7N9) human isolate. Such cross-reactive humoral immunity may provide vital first-line defense against fatal outcomes in case of an A(H7N9) pandemic.
人感染甲型流感病毒（H7N9）引起了人们对大流行的担忧。目前储备的 H7N9 疫苗是否具有诱导针对抗原漂移的 H7N9 病毒的交叉保护、非中和功能性抗体的能力尚未得到评估。在这里，我们表明，使用 MF59 或 AS03 佐剂的灭活 H7N9 疫苗接种可引发针对最近在中国第五波疫情中出现的抗原漂移的 H7N9 病毒的强大的、交叉反应的抗体依赖性细胞介导的细胞毒性介导和神经氨酸酶抑制功能性抗体，包括一种高致病性 H7N9 人分离株。这种交叉反应的体液免疫可能为应对 H7N9 大流行的致命后果提供重要的第一道防线。
