Maurel C, Chaignon M, Guédon J
Service de Néphrologie, Hypertension artérielle C.M.C. Foch, Suresnes, France.
Arch Mal Coeur Vaiss. 1987 Jun;80(6):839-43.
The acute hemodynamic effects of intravenous Nicardipine (N), a new calcium antagonist, were studied in 8 patients with moderate essential hypertension. The forearm arterial blood flow (ABF) was measured using plethysmography before and after N infusion: 1st step was obtained after infusion of 1 mg during 5 min then 1 mg during 25 min; a second step was obtained after the infusion of the same dose during the same time; thus a cumulative dosage of 4 mg was infused over a total duration of 60 mn. Systolic (SBP), diastolic (DBP) mean (MBP) blood pressure and heart rate (HR) were measured every minute using a non invasive device (Dinamap). Systemic vascular resistances (SVR) were calculated. Plasma concentration of N was determined at the beginning, in the middle and at the end of each step. Results are as follows: (table; see text) A 33% decrease in SVR was observed at the 2nd step whereas MBP decreased by 15% only. The date confirm the potent vasodilatory effect of intravenous N at low dosage; the BP alteration was moderate in relation to an increase in local blood flow. These results indicate that Nicardipine could be useful as part of the treatment of chronic arteriopathy and Raynaud disease.
对8例中度原发性高血压患者研究了新型钙拮抗剂静脉注射尼卡地平（N）的急性血流动力学效应。在输注N前后，使用体积描记法测量前臂动脉血流量（ABF）：第一步是在5分钟内输注1毫克，然后在25分钟内输注1毫克；第二步是在相同时间内输注相同剂量；因此，在60分钟的总时长内累计输注4毫克。使用无创设备（Dinamap）每分钟测量收缩压（SBP）、舒张压（DBP）、平均血压（MBP）和心率（HR）。计算全身血管阻力（SVR）。在每个步骤开始、中间和结束时测定N的血浆浓度。结果如下：（表格；见正文）在第二步观察到SVR下降33%，而MBP仅下降15%。数据证实静脉注射低剂量N具有强大的血管舒张作用；与局部血流增加相关，血压变化适中。这些结果表明，尼卡地平可用作慢性动脉病和雷诺病治疗的一部分。
