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细针穿刺细胞学诊断多发性结节性和腱性黄瘤——1例罕见病例报告

Multiple tuberous and tendinous xanthomas diagnosed on fine-needle aspiration cytology-report of a rare case.

作者信息

Tummidi Santosh, Kothari Kanchan, Rojekar Amey, Tiwari Ashish

机构信息

PDCC Dermatopathology, AIIMS, Bhopal, Madhya Pradesh, India.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai, Maharashtra, India.

出版信息

Diagn Cytopathol. 2019 Sep;47(9):939-942. doi: 10.1002/dc.24219. Epub 2019 Jun 6.

Abstract

Xanthomas are papulonodular skin lesions present in lipoprotein metabolism disorders, which result in cholesterol deposits in subcutaneous tissue, tendons, ligaments, periosteum, etc. A 11-year-old male presented with multiple soft tissue swellings, prominently over joints. Fine-needle aspiration (FNA) from multiple sites had similar appearance with foamy histocytes and giant cells. Oil Red O and polarized microscopy were also positive for fat. We describe an unusual case of tendinous and tuberous xanthoma diagnosed by cytology. Acquaintance with fine-needle aspiration cytology findings in xanthomas can help to avoid the need of surgical biopsy, as xanthomas can regress on medical therapy alone.

摘要

黄瘤是脂蛋白代谢紊乱时出现的丘疹结节性皮肤病变,会导致皮下组织、肌腱、韧带、骨膜等部位出现胆固醇沉积。一名11岁男性出现多处软组织肿胀,关节处尤为明显。对多个部位进行细针穿刺抽吸(FNA),结果显示有类似的泡沫状组织细胞和巨细胞。油红O染色和偏振显微镜检查脂肪也呈阳性。我们描述了一例通过细胞学诊断的肌腱和结节性黄瘤的罕见病例。熟悉黄瘤的细针穿刺细胞学检查结果有助于避免手术活检的必要性,因为黄瘤仅通过药物治疗即可消退。

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