Wang Hai-Tao, Xia Ming
Department of Urology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Department of Urology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China,
Urol Int. 2019;103(2):187-194. doi: 10.1159/000497311. Epub 2019 Jun 6.
This meta-analysis was to assess solifenacin and tolterodine in patients with overactive bladder.
We searched PubMed, the Cochrane Library, EMBASE, CNKI, Wanfang, and ClinicalTrials.gov databases for randomized controlled trials (RCTs). The efficacy endpoint was daily micturition frequency, daily urgency episodes, daily incontinence episodes, and micturition volume per voiding. The safety endpoint was the incidence of the rate of major bleeding, intracranial bleeding, and gastrointestinal bleeding.
Seven RCTs met the inclusion criteria and 1,318 patients were included. The meta-analysis showed that, compared with tolterodine, solifenacin was associated with similar daily micturition frequency, daily urgency episodes, daily incontinence episode, and micturition volume per voiding at 8 and 12 weeks of follow-up. Moreover, no significant difference was obtained in the incidence of dry mouth between solifenacin and tolterodine at 8 and 12 weeks of follow-up. However, tolterodine decreased the constipation rate at 12 weeks compared with solifenacin.
Solifenacin and tolterodine yielded similar results on daily micturition frequency, daily urgency episodes, daily incontinence episodes, micturition volume per voiding, and the incidence of dry mouth. However, tolterodine can decrease the constipation rate at 12 weeks compared with solifenacin.
本荟萃分析旨在评估索利那新和托特罗定在膀胱过度活动症患者中的疗效。
我们检索了PubMed、Cochrane图书馆、EMBASE、中国知网、万方数据库和ClinicalTrials.gov数据库中的随机对照试验（RCT）。疗效终点为每日排尿频率、每日尿急发作次数、每日尿失禁发作次数和每次排尿量。安全终点为大出血、颅内出血和胃肠道出血发生率。
7项RCT符合纳入标准，共纳入1318例患者。荟萃分析显示，与托特罗定相比，在随访8周和12周时，索利那新在每日排尿频率、每日尿急发作次数、每日尿失禁发作次数和每次排尿量方面效果相似。此外，在随访8周和12周时，索利那新和托特罗定口干发生率无显著差异。然而，与索利那新相比，托特罗定在12周时降低了便秘发生率。
索利那新和托特罗定在每日排尿频率、每日尿急发作次数、每日尿失禁发作次数、每次排尿量和口干发生率方面效果相似。然而，与索利那新相比，托特罗定在12周时可降低便秘发生率。
