含有多种多金属氧酸盐化合物的病毒阻断剂的体外抗菌作用及添加病毒阻断剂的湿纸巾的卫生效果

In vitro Antimicrobial Effects of Virus Block, Which Contains Multiple Polyoxometalate Compounds, and Hygienic Effects of Virus Block-Supplemented Moist Hand Towels.

作者信息

Dan Katsuaki, Katoh Naohiro, Matsuoka Takaaki, Fujinami Katsuyuki

机构信息

Research and Development Division, Research Organization of Biological Activity, Tokyo, Japan.

Mitsubishi Pencil Co., Yokohama, Japan.

出版信息

Pharmacology. 2019 Jun 6;104(1-2):1-15. doi: 10.1159/000500897.

DOI:10.1159/000500897

PMID:31170720

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6604270/

Abstract

BACKGROUND

Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs).

METHODS

We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an antibacterial agent. We also investigated the effectiveness of the addition of VB to moist hand towels in a study involving 120 volunteers. The time-dependent changes in metal ion concentrations in aqueous VB solution were analyzed using inductively coupled plasma atomic emission spectroscopy.

RESULTS

The metal elements in the aqueous VB solution remained stable for 12 weeks without undergoing time-dependent changes.

DISCUSSION

Further investigations were performed to study hand hygiene using moist hand towels in daily life settings. To this end, 120 volunteers provided 240 specimens that were used to investigate the presence of antibacterial compounds on the volunteers' hands before and after hand towel use. An aliquot of each specimen was suspended in phosphate-buffered saline and plated on agar media, and the number of colonies formed was counted. Normal bacterial flora found on the hands of the volunteers was investigated before and after the use of 4 different moist hand towels.

CONCLUSIONS

The effects of VB and PMs were superior to those of commercial moist hand towels, indicating that effective data were obtained that may be useful for the practical application of the tested items.

摘要

背景

历史证据已证实多金属氧酸盐（PMs）具有多方面的抗病毒功效。

方法

我们开展了一项研究，以调查构成病毒阻断剂（VB）的5种物质各自的抗菌效果，这5种物质包括3种具有抗菌和抗病毒活性的多金属氧酸盐、一种抗生素和一种抗菌剂。在一项涉及120名志愿者的研究中，我们还研究了在湿毛巾中添加VB的效果。使用电感耦合等离子体原子发射光谱法分析了VB水溶液中金属离子浓度随时间的变化。

结果

VB水溶液中的金属元素在12周内保持稳定，未发生随时间的变化。

讨论

进行了进一步研究，以探讨在日常生活环境中使用湿毛巾进行手部卫生的情况。为此，120名志愿者提供了240个样本，用于调查使用毛巾前后志愿者手上抗菌化合物的存在情况。将每个样本的一份等分试样悬浮在磷酸盐缓冲盐水中，并接种在琼脂培养基上，然后计算形成的菌落数量。在使用4种不同湿毛巾前后，对志愿者手上发现的正常细菌菌群进行了调查。