在健康清醒猫静脉注射盐酸氢吗啡酮后，静脉注射三种剂量的酒石酸布托啡诺或盐酸纳洛酮的抗伤害感受作用。

The antinociceptive effects of intravenous administration of three doses of butorphanol tartrate or naloxone hydrochloride following hydromorphone hydrochloride to healthy conscious cats.

作者信息

Simon Bradley T, Scallan Elizabeth M, Baetge Courtney L, Coursey Caleb D, Lizarraga Ignacio

机构信息

Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

出版信息

Vet Anaesth Analg. 2019 Jul;46(4):538-547. doi: 10.1016/j.vaa.2019.04.006. Epub 2019 Apr 30.

DOI:10.1016/j.vaa.2019.04.006

PMID:31171446

Abstract

OBJECTIVE

To evaluate thermal antinociception from intravenous (IV) administration of hydromorphone alone or followed by butorphanol or naloxone in cats.

STUDY DESIGN

Randomized, controlled, masked, crossover design.

ANIMALS

A group of eight adult female cats.

METHODS

Cats were administered six treatments of two IV injections 30 minutes apart: treatments S-S, two 0.9% saline; H-S, hydromorphone (0.1 mg kg) and saline; H-LB, hydromorphone and butorphanol (0.02 mg kg); H-MB, hydromorphone and butorphanol (0.1 mg kg); H-HB, hydromorphone and butorphanol (0.2 mg kg); H-N, hydromorphone and naloxone (0.04 mg kg). Skin temperature (ST), thermal threshold (TT) and sedation score (SS) were recorded before (baseline) and for 8 hours after the first injection. Percentage maximum possible effect (%MPE), thermal excursion (TE), TT, SS and ST were compared using two-way repeated measures anova or Friedman test followed by Tukey's or Dunn's multiple comparisons test when appropriate. Significance was set at p ≤ 0.05.

RESULTS

Data from seven cats were analyzed. There were no significant differences among treatments in baseline values, SS and within S-S over time. Compared with respective 0.5 hour values following hydromorphone administration, %MPE was significantly lower at 4-8 hours for H-S; at 3-8 hours for H-LB; at 4-8 hours for H-MB; at 6-8 hours for H-HB and at 1-8 hours for H-N. Compared with respective 0.5 hour values, TE was significantly lower at 4-8 hours for H-S; at 3-8 hours for H-LB; at 2 and 4-8 hours for H-MB; at 6 and 8 hours for H-HB and at 1-8 hours for H-N.

CONCLUSIONS AND CLINICAL RELEVANCE

Butorphanol and naloxone reduced hydromorphone-induced thermal antinociception. Butorphanol preserved hydromorphone antinociceptive properties better than naloxone. Butorphanol is recommended during non-life-threatening scenarios as a partial reversal agent for hydromorphone in cats.

摘要

目的

评估单独静脉注射氢吗啡酮或注射氢吗啡酮后再注射布托啡诺或纳洛酮对猫的热镇痛作用。

研究设计

随机、对照、双盲、交叉设计。

动物

一组8只成年雌性猫。

方法

给猫进行6种治疗，两次静脉注射间隔30分钟：治疗S-S，两次注射0.9%生理盐水；H-S，氢吗啡酮（0.1毫克/千克）和生理盐水；H-LB，氢吗啡酮和布托啡诺（0.02毫克/千克）；H-MB，氢吗啡酮和布托啡诺（0.1毫克/千克）；H-HB，氢吗啡酮和布托啡诺（0.2毫克/千克）；H-N，氢吗啡酮和纳洛酮（0.04毫克/千克）。在首次注射前（基线）和注射后8小时记录皮肤温度（ST）、热阈值（TT）和镇静评分（SS）。使用双向重复测量方差分析或Friedman检验比较最大可能效应百分比（%MPE）、热偏移（TE）、TT、SS和ST，在适当情况下随后进行Tukey或Dunn多重比较检验。显著性设定为p≤０.０５。

结果

分析了7只猫的数据。各治疗组的基线值、SS以及S-S组随时间的变化均无显著差异。与氢吗啡酮给药后各自的0.5小时值相比，H-S组在4至8小时的%MPE显著降低；H-LB组在3至8小时显著降低；H-MB组在4至8小时显著降低；H-HB组在6至8小时显著降低；H-N组在1至8小时显著降低。与各自的0.5小时值相比，H-S组在4至8小时的TE显著降低；H-LB组在3至8小时显著降低；H-MB组在2小时以及4至8小时显著降低；H-HB组在6和8小时显著降低；H-N组在1至8小时显著降低。