Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
Geriatr Gerontol Int. 2019 Aug;19(8):740-746. doi: 10.1111/ggi.13694. Epub 2019 Jun 7.
To evaluate the association between the amount and frequency of alcohol consumption and incident dementia in older Japanese adults using large sample size data over a long follow-up period.
This was a retrospective cohort study carried out in Japan. A total of 53 311 older adults were followed from 2008 to 2014. A health checkup questionnaire was used to assess the amount and frequency of alcohol consumption. The Dementia Scale of long-term care insurance was used as a measure of incident dementia. Cox proportional hazards models were used to calculate adjusted hazard ratios, with their 95% confidence intervals, for the incidence of dementia across the categories of alcohol consumption by sex.
During a 7-year follow-up period, 14 479 participants were regarded as having incident dementia. Compared with non-drinkers, the multivariate adjusted hazard ratios for participants with alcohol consumption ≤2 units per day, occasionally (0.88, 95% CI 0.81-0.96 in men and 0.84, 95% 0.79-0.90 in women) and daily (0.79, 95% 0.73-0.85 in men and 0.87, 95% 0.78-0.97 in women) were statistically significant, and the difference between occasional and daily consumption was only statistically significant in men; however, for participants with alcohol consumption >2 units per day, occasionally (0.91, 95% 0.71-1.16 in men and 1.09, 95% 0.72-1.67 in women) and daily (0.89, 95% 0.81-1.00 in men and 1.16, 95% 0.84-1.81 in women) were not significant.
Alcohol consumption of ≤2 units per day, occasionally or daily, could reduce the risk of incident dementia, with greater benefit for men with such daily consumption. Geriatr Gerontol Int 2019; 19: 740-746.
使用大样本量数据和长时间随访评估日本老年人饮酒量和饮酒频率与痴呆发病的相关性。
这是一项在日本进行的回顾性队列研究。共对 53311 名老年人进行了随访，随访时间从 2008 年到 2014 年。使用健康检查问卷评估饮酒量和饮酒频率。使用长期护理保险的痴呆量表作为痴呆发病的衡量标准。使用 Cox 比例风险模型计算不同性别饮酒类别下痴呆发病的调整后危险比及其 95%置信区间。
在 7 年的随访期间，有 14479 名参与者被认为患有痴呆症。与不饮酒者相比，每天饮酒≤2 单位、偶尔（男性 0.88，95%CI 0.81-0.96；女性 0.84，95%CI 0.79-0.90）和每天（男性 0.79，95%CI 0.73-0.85；女性 0.87，95%CI 0.78-0.97）饮酒者的多变量调整危险比具有统计学意义，且偶尔和每天饮酒者之间的差异仅在男性中具有统计学意义；然而，对于每天饮酒量超过 2 单位的参与者，偶尔（男性 0.91，95%CI 0.71-1.16；女性 1.09，95%CI 0.72-1.67）和每天（男性 0.89，95%CI 0.81-1.00；女性 1.16，95%CI 0.84-1.81）饮酒者的危险比无统计学意义。
每天≤2 单位、偶尔或每天饮酒可以降低痴呆发病的风险，对于每天饮酒的男性，这种风险降低的益处更大。
国际老年医学与老年学杂志 2019 年；19：740-746
