用微粒体单加氧酶抑制剂治疗感染小鼠可抑制伯氏疟原虫的氯喹抗性。
Suppression of the chloroquine resistance of Plasmodium berghei by treatment of infected mice with a microsomal monooxygenase inhibitor.
作者信息
Rabinovich S A, Kulikovskaya I M, Maksakovskaya E V, Chekhonadskikh T V, Pankova T G, Salganik R I
出版信息
Bull World Health Organ. 1987;65(3):387-9.
Administration of a combination of chloroquine and the copper-lysine complex, copper(lysine)(2), an inhibitor of microsomal monooxygenases, considerably decreased the parasitaemia level of mice infected with a chloroquine-resistant strain of Plasmodium berghei. When given separately, chloroquine and the complex had no antimalarial effect. Use of a combination of monooxygenase inhibitors and chloroquine therefore appears to be a promising addendum to the chemotherapy of malaria caused by chloroquine-resistant parasites.
氯喹与微粒体单加氧酶抑制剂铜赖氨酸络合物（铜（赖氨酸）₂）联合给药，可显著降低感染对氯喹耐药的伯氏疟原虫品系的小鼠的疟原虫血症水平。单独给药时，氯喹和该络合物均无抗疟作用。因此，使用单加氧酶抑制剂与氯喹的联合用药似乎是对由耐氯喹寄生虫引起的疟疾进行化疗的一种有前景的补充方法。
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