Loche S, Cappa M, Borrelli P, Faedda A, Crinò A, Cella S G, Corda R, Müller E E, Pintor C
First Department of Pediatrics, University of Cagliari, Italy.
Clin Endocrinol (Oxf). 1987 Aug;27(2):145-53. doi: 10.1111/j.1365-2265.1987.tb01139.x.
We have evaluated the plasma GH response to a single injection of 1 microgram/kg of GH-releasing hormone (GHRH)-40 in 15 obese children and 15 age-matched control children. Most of the obese children showed a subnormal plasma GH response to GHRH and the mean plasma GH integrated area (IC-GH) following stimulation was significantly smaller in obese than control children. Plasma somatomedin-C (SM-C) levels were significantly higher in obese than control children, and were negatively correlated with the peak plasma GH levels (r = -0.616, P less than 0.01) and the IC-GH (r = -0.554, P less than 0.02) after GHRH. Non-esterified fatty acids (NEFA) and fasting plasma insulin levels were also elevated in obese children, but did not correlate with the extent of plasma GH response to GHRH. These data confirm previous observations on the refractoriness of obese children to release GH after GHRH, and imply that it may be due to the feedback inhibition operated by the elevated plasma levels of SM-C.
我们评估了15名肥胖儿童和15名年龄匹配的对照儿童单次注射1微克/千克生长激素释放激素（GHRH）-40后血浆生长激素（GH）的反应。大多数肥胖儿童对GHRH的血浆GH反应低于正常水平，刺激后肥胖儿童的血浆GH积分面积（IC-GH）均值明显小于对照儿童。肥胖儿童的血浆生长调节素-C（SM-C）水平明显高于对照儿童，且与GHRH刺激后的血浆GH峰值水平（r = -0.616，P < 0.01）和IC-GH（r = -0.554，P < 0.02）呈负相关。肥胖儿童的非酯化脂肪酸（NEFA）和空腹血浆胰岛素水平也升高，但与血浆GH对GHRH反应的程度无关。这些数据证实了先前关于肥胖儿童对GHRH后释放GH反应迟钝的观察结果，并表明这可能是由于血浆SM-C水平升高所产生的反馈抑制作用。
