Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
J Diabetes Complications. 2019 Aug;33(8):511-515. doi: 10.1016/j.jdiacomp.2019.05.004. Epub 2019 May 11.
Our study aimed to investigate the influence of different glycemic statuses and their fasting plasma glucose/2-hour post-load glucose on uric acid level.
A total of 14,787 subjects were recruited after excluding subjects with medication for hyperuricemia or diabetes. Fasting plasma glucose (FPG), 2-hour post-load glucose (2hPG), and uric acid (UA) were measured. Then, subjects were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes.
After adjustment for clinical variables, in NGT group, there was no significant relationship found between UA level and FPG. However, there was a positive association between UA level and 2hPG (β = 0.003, 95% CI: 0.0020.004). A similar trend was also observed between UA level and 2hPG in IFG group (β = 0.004, 95% CI: 0.0000.009) and IGT group (β = 0.005, 95% CI: 0.002~0.008), but relationship between UA level and FPG remained insignificant. In diabetes group, UA level was negatively associated with both FPG (β = -0.008, 95% CI: -0.010 ~ -0.007) and 2hPG (β = -0.005, 95% CI: -0.006 ~-0.003).
In non-diabetic individuals, UA level increased with 2hPG, but not with FPG, and UA level was inversely associated with both FPG and 2hPG in diabetic population.
本研究旨在探讨不同血糖状态及其空腹血糖/餐后 2 小时血糖对尿酸水平的影响。
在排除服用降尿酸或降糖药物的患者后，共纳入 14787 例受试者。检测空腹血糖（FPG）、餐后 2 小时血糖（2hPG）和尿酸（UA）。然后，将受试者分为正常糖耐量（NGT）、空腹血糖受损（IFG）、糖耐量受损（IGT）和糖尿病。
在调整临床变量后，在 NGT 组中，UA 水平与 FPG 之间无显著关系。然而，UA 水平与 2hPG 呈正相关（β=0.003，95%CI：0.0020.004）。在 IFG 组（β=0.004，95%CI：0.0000.009）和 IGT 组（β=0.005，95%CI：0.0020.008）中也观察到 UA 水平与 2hPG 之间存在类似的趋势，但 UA 水平与 FPG 之间的关系仍不显著。在糖尿病组中，UA 水平与 FPG（β= -0.008，95%CI：-0.010-0.007）和 2hPG（β= -0.005，95%CI：-0.006~-0.003）均呈负相关。
在非糖尿病个体中，UA 水平随 2hPG 升高而升高，但与 FPG 无关，而在糖尿病人群中，UA 水平与 FPG 和 2hPG 均呈负相关。
