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儿童、青少年和青年患者行部分肾切除术和根治性肾切除术:相似的再入院率和术后并发症。

Partial and radical nephrectomy in children, adolescents, and young adults: Equivalent readmissions and postoperative complications.

机构信息

Division of Urologic Surgery, Duke University Medical Center, Durham, NC.

Department of Biostatistics, Duke University Medical Center, Durham, NC.

出版信息

J Pediatr Surg. 2019 Nov;54(11):2343-2347. doi: 10.1016/j.jpedsurg.2019.05.018. Epub 2019 May 31.

Abstract

OBJECTIVES

To compare and contrast the use of partial nephrectomy (PN) and radical nephrectomy (RN) in pediatric malignant renal tumors using a nationally representative database.

METHODS

The 2010-2014 Nationwide Readmissions Database (NRD) was used to obtain PN and RN select postoperative data. ICD-9-CM codes were used to identify children (<10 years), adolescents (10-19 years) and young adults (20-30 years) diagnosed with malignant renal tumors who were treated with a PN or RN. The presence of a 30-day readmission, occurrence of postoperative complications, cost, and length of stay (LOS) were studied and weighted logistic regression models were fit to test for associations.

RESULTS

There were 4330 weighted encounters (1289 PNs, 3041 RNs) that met inclusion criteria: 50.8% were children, 7.2% were adolescents, and 42% were young adults. Young adults had the highest rates of PN, whereas children had the highest rates of RN (p < 0.0001). Overall, no evidence was found to suggest a difference in odds between surgical modality and the presence of a 30-day readmission or postoperative complication. While PN was on average $9000 cheaper compared to RN overall, its cost was similar to that of RN for children. Similarly, PN patients had a shorter overall LOS compared to RN patients, but their LOS was similar to that of children who underwent RN.

CONCLUSION

There was no evidence of a difference in odds between RN and PN in terms of postoperative readmissions or in-hospital complication rates. Additionally, we observed descriptive differences in both cost and LOS between the surgical modalities across age groups.

TYPE OF STUDY

Retrospective comparative study (administrative database analysis).

LEVEL OF EVIDENCE

Level III.

摘要

目的

利用全国代表性数据库比较和对比儿童恶性肾肿瘤采用部分肾切除术 (PN) 和根治性肾切除术 (RN) 的情况。

方法

使用 2010-2014 年全国再入院数据库 (NRD) 获取 PN 和 RN 选择术后数据。使用 ICD-9-CM 代码识别接受 PN 或 RN 治疗的诊断为恶性肾肿瘤的儿童(<10 岁)、青少年(10-19 岁)和青年(20-30 岁)。研究 30 天再入院、术后并发症、费用和住院时间 (LOS) 的存在情况,并拟合加权逻辑回归模型以检验相关性。

结果

共有 4330 个加权病例符合纳入标准(1289 例 PN,3041 例 RN):50.8%为儿童,7.2%为青少年,42%为青年。年轻人行 PN 的比例最高,而儿童行 RN 的比例最高(p<0.0001)。总体而言,没有证据表明手术方式与 30 天再入院或术后并发症的发生之间存在差异。虽然总体而言,PN 比 RN 便宜 9000 美元,但对于儿童,其费用与 RN 相似。同样,PN 患者的总 LOS 比 RN 患者短,但与接受 RN 的儿童相似。

结论

在术后再入院或院内并发症发生率方面,RN 和 PN 之间的几率没有差异。此外,我们观察到在不同年龄组之间,手术方式在成本和 LOS 方面存在描述性差异。

研究类型

回顾性比较研究(行政数据库分析)。

证据水平

三级。

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