微藻和蓝细菌作为糖苷酶抑制剂的来源。

Microalgae and cyanobacteria as a source of glycosidase inhibitors.

作者信息

Cannell R J, Kellam S J, Owsianka A M, Walker J M

机构信息

Division of Biological and Environmental Sciences, Hatfield Polytechnic, UK.

出版信息

J Gen Microbiol. 1987 Jul;133(7):1701-5. doi: 10.1099/00221287-133-7-1701.

DOI:10.1099/00221287-133-7-1701

PMID:3117966

Abstract

Culture filtrates and organic solvent extracts of over 500 freshwater and marine eukaryotic microalgae and cyanobacteria were screened for the presence of glycosidase inhibitors. Rapid colorimetric assays were used to detect inhibitors of alpha-glucosidase, alpha-amylase and beta-galactosidase. Inhibitors were found from 38 species. The results suggest that microalgae and cyanobacteria have potential as a source of glycosidase inhibitors which may have clinical applications.

摘要

对500多种淡水和海洋真核微藻及蓝细菌的培养滤液和有机溶剂提取物进行了糖苷酶抑制剂筛选。采用快速比色法检测α-葡萄糖苷酶、α-淀粉酶和β-半乳糖苷酶的抑制剂。从38个物种中发现了抑制剂。结果表明，微藻和蓝细菌有可能作为糖苷酶抑制剂的来源，这些抑制剂可能具有临床应用价值。