基于结构定义的α-四氢萘酚的手性高价碘试剂。
Structurally Defined α-Tetralol-Based Chiral Hypervalent Iodine Reagents.
作者信息
Hokamp Tobias, Wirth Thomas
机构信息
School of Chemistry , Cardiff University , Main Building, Park Place, Cardiff CF10 3AT , U.K.
出版信息
J Org Chem. 2019 Jul 5;84(13):8674-8682. doi: 10.1021/acs.joc.9b01315. Epub 2019 Jun 21.
PMID:31179710
Abstract
A novel class of chiral hypervalent iodine reagents containing an α-tetralol scaffold is introduced. Iodine triacetate is employed in a key step as a highly selective and efficient iodinating reagent for a short and convenient synthesis of iodine(III) derivatives. Solid-state X-ray analyses offer valuable structural information, while reactivities and stereoselectivities are investigated in three model reactions.
摘要
介绍了一类新型的含有α-四氢萘醇骨架的手性高价碘试剂。在关键步骤中使用三乙酸碘作为高选择性和高效的碘化试剂，用于简短便捷地合成碘（III）衍生物。固态X射线分析提供了有价值的结构信息，同时在三个模型反应中研究了反应活性和立体选择性。
Zotero 插件