以心房血栓形成和肺栓塞为表现的高级别骨肉瘤心血管复发：一例报告及儿科文献综述
Cardiovascular recurrence of high-grade osteosarcoma presenting as atrial thrombosis and pulmonary embolism: A case report and review of the pediatric literature.
作者信息
Ting Michelle, Rodriguez Marco, Gowda Srinath T, Anders Marc, Qureshi Athar M, Grimes Amanda
机构信息
a Division of Pediatric Hematology and Oncology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine , Houston , Texas.
b Division of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine , Houston , Texas.
出版信息
Pediatr Hematol Oncol. 2019 May;36(4):244-251. doi: 10.1080/08880018.2019.1624902. Epub 2019 Jun 8.
In the era of neoadjuvant and adjuvant chemotherapy, extrapulmonary involvement by high-grade osteosarcoma (HGOS) is rare. Importantly however, HGOS metastasis in the form of cardiovascular tumor thrombus portends a dismal prognosis. Thus, prompt and accurate identification of tumor thrombus is crucial. We report here two unique cases of recurrent HGOS, presenting as thrombotic events, in order to increase awareness and index of suspicion among practitioners regarding this presentation. Additionally, we review 14 previously reported pediatric cases of cardiovascular metastatic HGOS.
在新辅助化疗和辅助化疗时代，高级别骨肉瘤（HGOS）的肺外受累情况较为罕见。然而，重要的是，HGOS以心血管肿瘤血栓的形式发生转移预示着预后不良。因此，及时准确地识别肿瘤血栓至关重要。我们在此报告两例独特的复发性HGOS病例，表现为血栓形成事件，以提高从业者对这种表现的认识和怀疑指数。此外，我们回顾了14例先前报道的小儿心血管转移性HGOS病例。
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