外周神经纤维瘤病与8号染色体上DNA标记的连锁分析。
Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.
作者信息
Diehl S R, Boehnke M, Collins F S, Erickson R P, Karolyi I J, Ploughman L M, Pericak-Vance M A, Aylsworth A S, Roses A D
机构信息
Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.
出版信息
J Med Genet. 1987 Sep;24(9):532-4. doi: 10.1136/jmg.24.9.532.
Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod less than or equal to -2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.
利用位于8号染色体上的两个DNA标记，对一个大型美籍高加索人谱系中的外周神经纤维瘤病（NF）基因的连锁关系进行了评估。位于8q24的甲状腺球蛋白基因座与NF基因的连锁关系在21厘摩（cM）处被排除（对数优势比小于或等于-2.0）。位于8p12的组织纤溶酶原激活物基因座的数据排除了与4厘摩（cM）的连锁关系。这些结果排除了8号染色体上20%至30%的区域作为该家族中NF基因可能的图谱定位。对这两个DNA标记的比较排除了它们之间0.5厘摩（cM）的连锁关系。
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