Nunez D J, Williams P F, Herrick A L, Evans D B, McColl K E
Renal Unit, Addenbrooke's Hospital, Cambridge, UK.
Nephrol Dial Transplant. 1987;2(4):271-4.
A woman with acute intermittent porphyria and a man with variegate porphyria developed chronic renal failure in middle age. After periods on haemodialysis, both received successful cadaveric renal transplants. On the basis of animal porphyrinogenicity studies prednisolone and azathioprine were used in preference to cyclosporin as immunosuppressive agents. Neither of the patients showed any evidence of activation of their porphyria during, or following, transplantation. The findings in these two patients and a review of two previous reports indicate that acute porphyria is not a contraindication to renal transplantation.
一名患有急性间歇性卟啉病的女性和一名患有混合型卟啉病的男性在中年时发展为慢性肾衰竭。经过一段时间的血液透析后，两人均成功接受了尸体肾移植。基于动物卟啉生成性研究，优先使用泼尼松龙和硫唑嘌呤而非环孢素作为免疫抑制剂。两名患者在移植期间及移植后均未表现出卟啉病激活的任何迹象。这两名患者的研究结果以及对之前两份报告的回顾表明，急性卟啉病并非肾移植的禁忌证。
