Kalden J R
Institut und Poliklinik für klinische Immunologie und Rheumatologie der Universität Erlangen-Nürnberg.
Onkologie. 1987 Aug;10(4):240-4. doi: 10.1159/000216412.
In cases of hairy cell leukemia, chronic myelogenous leukemia, and in benign larynx papilloma, interferon alpha has proved to be a valuable therapeutic principle. Regarding most malignant diseases, however, we are still at the beginning of the therapeutic application of cytokines. New therapeutic strategies include the combination of cytokines together with cytotoxic substances, the combination of in vitro activated T-lymphocytes and natural killer (NK) cells together with cytokines, and, finally, the application of cytokine cocktails. Based on presently performed clinical studies, a slight optimism might be justified with regard to the development of new therapeutic modalities for Hodgkin's disease as well as non-Hodgkin's lymphomas and solid tumors.
在毛细胞白血病、慢性粒细胞白血病以及良性喉乳头状瘤的治疗中，α干扰素已被证明是一种有价值的治疗原则。然而，对于大多数恶性疾病而言，我们在细胞因子的治疗应用方面仍处于起步阶段。新的治疗策略包括将细胞因子与细胞毒性物质联合使用、将体外激活的T淋巴细胞和自然杀伤（NK）细胞与细胞因子联合使用，以及最后应用细胞因子鸡尾酒疗法。基于目前所进行的临床研究，对于霍奇金病、非霍奇金淋巴瘤以及实体瘤新治疗模式的发展，或许有理由抱有一丝乐观态度。
