Ozturk Thomas Gulten, Tutar Engin, Tokuc Gulnur, Oktem Sedat
Pediatrics, Dr. Lutfi Kirdar Training & Research Hospital, Istanbul, TUR.
Cureus. 2019 Mar 22;11(3):e4302. doi: 10.7759/cureus.4302.
Aim Although the relationship between 25-hydroxy (25-OH) vitamin D and asthma is known, it is unknown if 25-OH vitamin D levels are correlated with asthma severity in pediatric patients. The aim of this study was to compare the blood 25-OH vitamin D levels of asthma patients and healthy control groups and to evaluate any correlation between asthma severity and blood 25-OH vitamin D levels in pediatric asthma patients. Methods This is a cross-sectional study which shows the 25-OH vitamin D levels of asthma patients and compared to healthy controls followed by a tertiary pediatric clinic. We investigated the effect of 25-OH vitamin D levels on the severity of asthma. The severity of asthma was determined mainly by the duration of asthma diagnosis, a number of attacks in the previous year, anti-inflammatory medication usage in a previous year, atopy presence in the family, skin prick test positivity, and immunoglobulin E (IgE) levels of asthma patients. Results Compared with control groups, asthma patients had significantly lower 25-OH vitamin D, calcium (Ca) levels, and higher number of patients who had a 25-OH vitamin D deficiency, (p<0.0001, p<0.0001, p<0.0001, respectively). We found a correlation between blood 25-OH vitamin D levels and force expiratory capacity in one second (FEV1) and forced vital capacity (FVC) respectively (p< 0.001, r=0.512), (p< 0.001, r=0.513). There was an association between FEV1, FVC and blood 25-OH vitamin D levels in terms of deficient levels (<20 ng/mL) or insufficient levels (≥20 and <30 ng/mL) (p<0.001, r=0.459), (p< 0.001, r=0.450), respectively. Conclusions The 25-OH vitamin D levels were lower in pediatric asthma patients with worse spirometry results. Effects of Vitamin D supplementation need to be evaluated by well-designed studies.
目的 虽然已知25-羟基（25-OH）维生素D与哮喘之间的关系，但尚不清楚25-OH维生素D水平是否与儿科患者的哮喘严重程度相关。本研究的目的是比较哮喘患者和健康对照组的血液25-OH维生素D水平，并评估儿科哮喘患者的哮喘严重程度与血液25-OH维生素D水平之间的相关性。方法 这是一项横断面研究，展示了哮喘患者的25-OH维生素D水平，并与一家三级儿科诊所的健康对照组进行比较。我们研究了25-OH维生素D水平对哮喘严重程度的影响。哮喘严重程度主要由哮喘诊断持续时间、前一年的发作次数、前一年的抗炎药物使用情况、家族中特应性疾病的存在、皮肤点刺试验阳性以及哮喘患者血清免疫球蛋白E（IgE）水平来确定。结果 与对照组相比，哮喘患者的25-OH维生素D、钙（Ca）水平显著更低，且25-OH维生素D缺乏的患者数量更多（分别为p<0.0001、p<0.0001、p<0.0001）。我们分别发现血液25-OH维生素D水平与一秒用力呼气容积（FEV1）和用力肺活量（FVC）之间存在相关性（p<0.001，r=0.512），（p<0.001，r=0.513）。就缺乏水平（<20 ng/mL）或不足水平（≥20且<30 ng/mL）而言，FEV1、FVC与血液25-OH维生素D水平之间存在关联（分别为p<0.001，r=0.459），（p<0.001，r=0.450）。结论 肺功能测定结果较差的儿科哮喘患者的25-OH维生素D水平较低。需要通过精心设计的研究来评估补充维生素D的效果。
