Solerte S B, Fioravanti M, Ferrari E
Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.
Ric Clin Lab. 1987 Jul-Sep;17(3):251-8. doi: 10.1007/BF02912539.
Plasma fibronectin might be considered as an indicator of early and advanced microvascular damage in diabetic patients. We have therefore studied plasma fibronectin, using a radial immunodiffusion technique (LC-Partigen Fibronectin), in insulin-dependent and non-insulin-dependent diabetic patients with and without microangiopathic and neurological complications, i.e. retinopathy, nephropathy and autonomic and peripheral neuropathy. Steady and progressive increases of plasma fibronectin levels in association with the worsening of both diabetic retinopathy and nephropathy have been observed. However, significant variations of plasma fibronectin levels were already found in diabetic patients without microangiopathy when compared with healthy control subjects. Fibronectin levels were also higher in diabetic patients with autonomic and peripheral neuropathy than in control subjects and diabetic patients without neurological changes. The evaluation of plasma fibronectin by a specific radial immunodiffusion procedure might represent an important approach in the study and prevention of diabetic microcirculatory disorders.
血浆纤维连接蛋白可被视为糖尿病患者早期和晚期微血管损伤的一个指标。因此，我们采用放射免疫扩散技术（LC-帕替吉宁纤维连接蛋白），对有或无微血管病变及神经并发症（即视网膜病变、肾病以及自主神经和周围神经病变）的胰岛素依赖型和非胰岛素依赖型糖尿病患者的血浆纤维连接蛋白进行了研究。已观察到血浆纤维连接蛋白水平随着糖尿病视网膜病变和肾病的恶化而稳步且逐渐升高。然而，与健康对照受试者相比，在没有微血管病变的糖尿病患者中已发现血浆纤维连接蛋白水平存在显著差异。有自主神经和周围神经病变的糖尿病患者的纤维连接蛋白水平也高于对照受试者以及没有神经病变的糖尿病患者。通过特定的放射免疫扩散程序评估血浆纤维连接蛋白可能是研究和预防糖尿病微循环障碍的一种重要方法。
