Alland A, Hartmann D J, Loupy G, Lechevalier D, Ville G, Cotisson A, Ulrich J Y
Pathol Biol (Paris). 1984 Feb;32(2):115-21.
Fibronectin (by laser nephelometry) and collagen IV blood levels (by radioimmunoassay) were studied in 183 diabetics and compared with 101 non diabetic patients. Diabetics have more collagen IV and less fibronectin than non diabetics. Divergence has increased since 20 years old; fibronectin blood levels is always low in diabetics, even in the young. Collagen IV is higher in diabetics with angiopathy, and specially if insulin dependent. Diabetics which have a good control have normals levels. In the other hand when HBA1C greater than or equal to 9%, collagen IV blood level increases quickly and fibronectin level decreases. The importance of the antidiabetic treatment is underlined.
对183名糖尿病患者的纤连蛋白（通过激光散射比浊法测定）和IV型胶原血水平（通过放射免疫分析法测定）进行了研究，并与101名非糖尿病患者进行了比较。糖尿病患者比非糖尿病患者有更多的IV型胶原和更少的纤连蛋白。自20岁起差异就已增大；糖尿病患者的纤连蛋白血水平一直较低，即使是年轻人。IV型胶原在患有血管病变的糖尿病患者中更高，尤其是胰岛素依赖型患者。血糖控制良好的糖尿病患者水平正常。另一方面，当糖化血红蛋白大于或等于9%时，IV型胶原血水平迅速升高而纤连蛋白水平降低。强调了抗糖尿病治疗的重要性。
