Yee A L, Cantekin E I
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pennsylvania.
Acta Otolaryngol. 1987 Sep-Oct;104(3-4):261-9. doi: 10.3109/00016488709107327.
The combined effect of changes in middle ear (ME) gas composition and changes in systemic arterial blood oxygenation on total ME pressure was studied in three anesthetized juvenile Rhesus monkeys (Macaca mulatta). The gas composition of the ME was altered by ME inflation (politzerization) using either pure nitrogen, oxygen, or carbon dioxide while the animal was ventilated with either room air or 100% oxygen at constant carbon dioxide blood gas tension. Total ME pressure was measured indirectly by tympanometry (acoustic impedance) for a 5-hour duration. The changes in ME pressure were consistent and reproducible, exhibiting different pressure-time patterns unique for each gas. Carbon dioxide resulted in the most rapid decrease in ME pressure, followed by oxygen. The slowest decrease was observed in experiments with nitrogen. The systemic hyperoxygenation had little or no effect on the results. The findings were explained by the differences in relative permeabilities of these gases influencing ME gas diffusion, but the lack of systemic hyperoxygenation effect remained unexplained.
在三只麻醉的幼年恒河猴（猕猴）中，研究了中耳（ME）气体成分变化和全身动脉血氧合变化对总中耳压力的综合影响。在动物以恒定的二氧化碳血气张力用室内空气或100%氧气通气时，通过使用纯氮气、氧气或二氧化碳进行中耳充气（波利策尔法）来改变中耳的气体成分。通过鼓室导抗测量法（声阻抗）间接测量总中耳压力，持续5小时。中耳压力的变化是一致且可重复的，每种气体都呈现出独特的压力-时间模式。二氧化碳导致中耳压力下降最快，其次是氧气。在氮气实验中观察到下降最慢。全身高氧对结果几乎没有影响。这些发现可以通过影响中耳气体扩散的这些气体相对渗透率的差异来解释，但全身高氧效应的缺乏仍无法解释。
