Skala L Z, Abramian R G, Shanina A G, Razgarova N K, Nekhorosheva A G
Antibiot Med Biotekhnol. 1987 Jul;32(7):520-3.
Pharmacokinetic studies showed that endobronchial administration of benzylpenicillin and gentamicin to patients with acute and chronic pneumonia unlike intramuscular administration provided the antibiotic concentrations in bronchial secretions effective against middle sensitive and moderately resistant strains of microorganisms within 1-5 hours. Such concentrations maintained at the levels sufficient for inhibiting sensitive microflora growth for 24-36 hours with the use of benzylpenicillin and for 6 days with the use of gentamicin. This also lowered the risk of toxic complications.
药代动力学研究表明，与肌肉注射不同，对急慢性肺炎患者进行支气管内给予苄青霉素和庆大霉素，可在1至5小时内使支气管分泌物中的抗生素浓度对中度敏感和中度耐药的微生物菌株有效。使用苄青霉素时，这些浓度可维持在足以抑制敏感菌群生长的水平24至36小时，使用庆大霉素时可维持6天。这也降低了毒性并发症的风险。
