Holloway B W, Kearney P P, Lyon B R
Department of Genetics, Monash University, Clayton, Victoria, Australia.
Antonie Van Leeuwenhoek. 1987;53(1):47-53. doi: 10.1007/BF00422634.
The availability of recombinant DNA techniques has enabled the successful genetic analysis and manipulation of a range of C1 utilizing microorganisms. It has resulted in the identification of genes of interest on both plasmids and the chromosome; enabled the linkage of chromosomal genes to be determined; established the function and regulatory patterns of genes essential for utilization of C1 compounds and provided information on the evolution of methanogenic bacteria.