Ji Y C, Zhan Y B, Liu X Z, Zhang Z Y
Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhonghua Yi Xue Za Zhi. 2019 Jun 4;99(21):1641-1644. doi: 10.3760/cma.j.issn.0376-2491.2019.21.010.
To investigate the prognostic values of preoperative prognostic nutritional index (PNI) in patients with lower-grade gliomas. In the study, 379 patients with pathological diagnosis of lower-grade gliomas were enrolledwhich were confirmed in The First Affiliated Hospital of Zhengzhou University (2011-02 to 2016-05). Kaplan-Meier method was used to calculate the survival rates. log-rank was used to calculate the differences in group. Cox regression model was used to conduct multivariate analysis. The cutoff value of PNI was 46.70. The median survival time of PNI≤47.80 and PNI>47.80 subgroups were 46.76 and 67.37 months with statistical significance (0.001). High PNI predicted a better survival rate. Multivariate survival analysis demonstrated that low PNI was an independent risk factor to evaluate the prognosis of glioma patients. In lower-grade gliomas, high PNI predicted better survivals in TERT mutation only (0.003) and triple-negative group (0.007). In lower-grade gliomas, low PNI predicts worse survivals and PNI have differential prognostic significances in molecular groups of lower-grade gliomas.
探讨术前预后营养指数（PNI）在低级别胶质瘤患者中的预后价值。本研究纳入了379例经病理诊断为低级别胶质瘤的患者，这些患者均在郑州大学第一附属医院确诊（2011年2月至2016年5月）。采用Kaplan-Meier法计算生存率，log-rank检验用于计算组间差异，Cox回归模型用于进行多因素分析。PNI的临界值为46.70。PNI≤47.80和PNI>47.80亚组的中位生存时间分别为46.76个月和67.37个月，差异具有统计学意义（P=0.001）。高PNI预示着更好的生存率。多因素生存分析表明，低PNI是评估胶质瘤患者预后的独立危险因素。在低级别胶质瘤中，高PNI仅在TERT突变组（P=0.003）和三阴性组（P=0.007）中预示着更好的生存率。在低级别胶质瘤中，低PNI预示着更差的生存率，且PNI在低级别胶质瘤的分子亚组中具有不同的预后意义。
