Key Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Key Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Nat Commun. 2019 Jun 12;10(1):2562. doi: 10.1038/s41467-019-10544-y.
Cadmium (Cd) accumulation in rice grain poses a serious threat to human health. While several transport systems have been reported, the complicity of rice Cd transport and accumulation indicates the necessity of identifying additional genes, especially those that are responsible for Cd accumulation divergence between indica and japonica rice subspecies. Here, we show that a gene, OsCd1, belonging to the major facilitator superfamily is involved in root Cd uptake and contributes to grain accumulation in rice. Natural variation in OsCd1 with a missense mutation Val449Asp is responsible for the divergence of rice grain Cd accumulation between indica and japonica. Near-isogenic line tests confirm that the indica variety carrying the japonica allele OsCd1 can reduce the grain Cd accumulation. Thus, the japonica allele OsCd1 may be useful for reducing grain Cd accumulation of indica rice cultivars through breeding.
镉(Cd)在水稻中的积累对人类健康构成严重威胁。虽然已经报道了几种转运系统,但水稻 Cd 转运和积累的复杂性表明有必要识别其他基因,特别是那些负责籼稻和粳稻亚种之间 Cd 积累差异的基因。在这里,我们表明,属于主要易化因子超家族的一个基因 OsCd1 参与根 Cd 的摄取,并有助于水稻籽粒的积累。OsCd1 基因的自然变异,带有一个错义突变 Val449Asp,是导致籼稻和粳稻籽粒 Cd 积累差异的原因。近等基因系试验证实,携带粳稻等位基因 OsCd1 的籼稻品种可以减少籽粒 Cd 积累。因此,粳稻等位基因 OsCd1 可能通过育种用于降低籼稻品种的籽粒 Cd 积累。