Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.
Department of Medical Pharmacology, Kirikkale University Faculty of Medicine, Kırıkkale Üniversitesi Ankara Yolu 7. Km, 71450, Yahşihan/Kırıkkale, Turkey.
Int Urol Nephrol. 2019 Aug;51(8):1387-1394. doi: 10.1007/s11255-019-02194-2. Epub 2019 Jun 11.
Contrast-induced nephropathy (CIN) is one of the side effects of diagnostic procedures. Oxidative stress plays an important role in CIN's pathophysiology. Dexpanthenol (Dexp) is a substance with antioxidant efficacy. We investigated the likely protective effects of dexpanthenol for CIN.
Twenty-four Sprague-Dawley rats were divided randomly into four groups of 6 rats; control (group 1), Dexp (group 2), CIN (group 3) and Dexp + CIN (group 4). All rats were restricted of water moderately to facilitate of nephrotoxicity. Dexp was administered into the intraperitoneally at a dose of 500 mg/kg for 5 days in groups 2 and 4. The same amount of saline was applied via intraperitoneally to group 1 and 3. In CIN and Dexp + CIN groups, L-NAME (10 mg/kg), tenoxicam (0.5 mg/kg) and sodium amidotrizoate (10 ml/kg) were administered on the 4th day via the tail vein for CIN. All rats were euthanized on the 6th day and samples for biochemical and pathological evaluations were collected.
When the Dexp + CIN group and the CIN group were compared, it was found to be provide a significant decline at the level of acute tubular injury and necrosis in kidney biopsies by dexp. Furthermore Dexp significantly reduced the serum cystatin C (Cys-C) levels, not serum creatinine. There was no statistically significant difference between the groups in total oxidant and antioxidant levels.
Dexpanthenol did not have significant effect on oxidative stress of acute kidney injury on this rat model. However, it has ameliorated serum Cys-C levels and histopathological findings of CIN.
对比剂肾病（CIN）是诊断程序的副作用之一。氧化应激在 CIN 的病理生理学中起着重要作用。泛醇（Dexp）是一种具有抗氧化功效的物质。我们研究了泛醇对 CIN 的可能保护作用。
将 24 只 Sprague-Dawley 大鼠随机分为 4 组，每组 6 只；对照组（第 1 组）、Dexp 组（第 2 组）、CIN 组（第 3 组）和 Dexp+CIN 组（第 4 组）。所有大鼠均适度限制水摄入以促进肾毒性。第 2 组和第 4 组大鼠连续 5 天腹腔内给予 500mg/kg 的 Dexp，第 1 组和第 3 组大鼠腹腔内给予等体积生理盐水。在 CIN 和 Dexp+CIN 组中，第 4 天经尾静脉给予 L-NAME（10mg/kg）、替诺昔康（0.5mg/kg）和氨甲蝶呤钠（10ml/kg）以诱导 CIN。所有大鼠于第 6 天安乐死，并收集生化和病理评估样本。
与 CIN 组相比，Dexp+CIN 组肾活检中急性肾小管损伤和坏死程度明显下降。此外，Dexp 显著降低了血清胱抑素 C（Cys-C）水平，而不是血清肌酐。各组总氧化剂和抗氧化剂水平无统计学差异。
在该大鼠模型中，泛醇对急性肾损伤的氧化应激没有显著影响。然而，它改善了 CIN 的血清 Cys-C 水平和组织病理学发现。
