Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer.

Lamina-associated polypeptide 2 (LAP2; encoded by ), is a nuclear protein that may affect chromatin regulation and gene expression through dynamically binding to nuclear lamin. (LAP2) plays dual roles of either suppressing or promoting proliferation of cells, depending on the status of the cell. It has been reported that is up-regulated in various cancer types. However, its function in lung cancer has not been studied yet. A series of clinical microarray datasets for lung cancer were investigated to demonstrate the expression of TMPO. The transcription of TMPO gene in human lung cancer was analyzed using Oncomine platform (www.oncomine.org) according to the standardized procedures described previously. Four separate datasets (Hou Lung, Okayama Lung, Beer Lung, and Garber Lung) were analyzed. Here, we show that is over-expressed in lung cancer tissues, and that a high level of indicates a poor prognosis in lung cancer patients. Knockdown of in lung cancer cells inhibits cell proliferation and induces apoptosis. Also, down-regulation of leads to an impaired metastatic ability of tumor cells. A nude mice tumor model show that knockdown of suppresses tumor formation in vivo. Collectively, this study suggests as an oncogene and a novel prognostic gene in lung cancer.