Jahromi Mohamed, Al-Otaibi Torki, Othman Nashwa, Gheith Osama, Mahmoud Tarek, Nair Prasad, Halim Medhat A, Nampoory Narayanam
Clinical Research, Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait.
Nephrology Department, Hamid Al-Essa Organ Transplant Center, Kuwait City, Kuwait.
Diabetes Metab Syndr Obes. 2019 May 20;12:731-742. doi: 10.2147/DMSO.S195859. eCollection 2019.
New onset diabetes after transplantation (NODAT) is a serious metabolic complication following kidney transplantation. Although beta-cell dysfunction is considered the main contributing factor in the development of this complication, its exact etiology is yet to be identified. We aimed to investigate NODAT among kidney transplant cohort in Kuwait with special stress on correlation between its risk factors and interferon gamma genotyping. We surveyed 309 kidney transplant recipients from Hamed Al Essa Transplantation Centre, Kuwait. The participants were categorized into cohorts according to the development of NODAT diagnosed based on the American Diabetes Association guidelines. Statistical analyses were performed using SPSS software. We genotyped interferon gamma as the leading immunosignature for T lymphocyte. No relationship between ethnicity and the development of NODAT was identified. However, there was a significant difference in age between cohorts. Younger patients demonstrated a lower rate of NODAT while, NODAT reached its maximum in 40-60-year age group. IFNG TT genotype was significantly associated with NODAT (=0.005), while IFNG AA was considerably higher in the non-NODAT group. Beside the conventional contributing factors of NODAT, our results might represent a suitable platform for a larger cytokine and chemokine spectrum genotyping.
移植后新发糖尿病（NODAT）是肾移植后一种严重的代谢并发症。尽管β细胞功能障碍被认为是该并发症发生的主要促成因素，但其确切病因仍有待确定。我们旨在调查科威特肾移植队列中的NODAT情况，特别关注其危险因素与干扰素γ基因分型之间的相关性。我们对科威特哈米德·艾尔·埃萨移植中心的309名肾移植受者进行了调查。根据基于美国糖尿病协会指南诊断的NODAT发生情况，将参与者分为不同队列。使用SPSS软件进行统计分析。我们将干扰素γ基因分型作为T淋巴细胞的主要免疫特征。未发现种族与NODAT发生之间存在关联。然而，各队列之间年龄存在显著差异。年轻患者的NODAT发生率较低，而在40 - 60岁年龄组中NODAT发生率最高。IFNG TT基因型与NODAT显著相关（=0.005），而IFNG AA在非NODAT组中明显更高。除了NODAT的传统促成因素外，我们的结果可能为更大规模的细胞因子和趋化因子谱基因分型提供一个合适的平台。
